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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6592
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pubmed:dateCreated |
1996-9-18
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pubmed:databankReference |
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pubmed:abstractText |
An abundant cDNA enriched in Spemann's organizer, cerberus, was isolated by differential screening. It encodes a secreted protein that is expressed in the anterior endomesoderm. Microinjection of cerberus mRNA into Xenopus embryos induces ectopic heads, and duplicated hearts and livers. The results suggest a role for a molecule expressed in the anterior endoderm in the induction of head structures in the vertebrate embryo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
382
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
595-601
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8757128-Amino Acid Sequence,
pubmed-meshheading:8757128-Animals,
pubmed-meshheading:8757128-Base Sequence,
pubmed-meshheading:8757128-Blastomeres,
pubmed-meshheading:8757128-Cell Polarity,
pubmed-meshheading:8757128-DNA, Complementary,
pubmed-meshheading:8757128-DNA Primers,
pubmed-meshheading:8757128-Digestive System,
pubmed-meshheading:8757128-Embryonic Induction,
pubmed-meshheading:8757128-Endoderm,
pubmed-meshheading:8757128-Gastrula,
pubmed-meshheading:8757128-Head,
pubmed-meshheading:8757128-In Situ Hybridization,
pubmed-meshheading:8757128-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:8757128-Mesoderm,
pubmed-meshheading:8757128-Molecular Sequence Data,
pubmed-meshheading:8757128-Proteins,
pubmed-meshheading:8757128-RNA, Messenger,
pubmed-meshheading:8757128-Tail,
pubmed-meshheading:8757128-Ultraviolet Rays,
pubmed-meshheading:8757128-Xenopus,
pubmed-meshheading:8757128-Xenopus Proteins
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pubmed:year |
1996
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pubmed:articleTitle |
Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer.
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pubmed:affiliation |
Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, 90095-1737, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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