Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-9-23
pubmed:abstractText
Tissue factor pathway inhibitor (TFPI) was demonstrated in the kidneys of normal rabbits and in a crescentic model of glomerulonephritis (GN), where fibrin is a key mediator of injury. In normal kidneys, TFPI was expressed in glomeruli, in intrarenal arteries and the interstitial capillary network. Evidence for TFPI synthesis in vivo was provided by in situ demonstration of TFPI mRNA in glomeruli and intrarenal vessels and by biosynthetic labeling of TFPI released from glomeruli in vitro. In fibrin-dependent crescentic GN, glomerular TFPI synthesis and expression was initially decreased (TFPI antigen at 24 h, 7.5 +/- 0.7 ng/10(3) glomeruli; normal, 11.1 +/- 0.9 ng/10(3) glomeruli, P < 0.02) and subsequently returned to normal values. Plasma TFPI levels increased progressively throughout the evolution of disease. In vivo inhibition of TFPI using an anti-TFPI antibody during the development of GN significantly increased glomerular fibrin deposition (GFD) and exacerbated renal impairment. Infusion of recombinant human TFPI significantly reduced development of GFD (fibrin scores, TFPI treated 0.82 +/- 0.11, control 1.49 +/- 0.14, P < 0.01), proteinuria and renal impairment. This data indicates that TFPI is synthesized and expressed in normal glomeruli and is down regulated in the early response to glomerular injury. Endogenous glomerular TFPI and treatment with recombinant TFPI reduces GFD and injury in fibrin dependent GN. TFPI has the potential to be of therapeutic benefit in the management of fibrin dependent human GN.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-1212801, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-126330, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-1412217, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-1514170, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-1596565, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-1641662, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-1794748, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-1890807, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-1899482, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-1909195, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-2002624, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-2070076, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-2207329, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-2440339, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-2644974, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-2719077, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-3034984, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-3089018, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-3112298, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-3170746, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-3238648, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-3413731, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-3422166, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-342668, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-3741774, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-3807314, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-4160258, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-4348668, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-6312838, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-7482419, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-7495298, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-7519601, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-7523756, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-7706485, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-794557, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-8005109, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-8029799, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-8054453, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-8231028, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-8342923, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-8497849, http://linkedlifedata.com/resource/pubmed/commentcorrection/8755641-8514893
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
98
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
325-35
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Renal expression of tissue factor pathway inhibitor and evidence for a role in crescentic glomerulonephritis in rabbits.
pubmed:affiliation
Centre for Inflammatory Diseases, Department of Medicine, Monash University, Clayton, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't