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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1996-12-23
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pubmed:abstractText |
The muscle-derived factors required for survival of embryonic motoneurons are not clearly identified. Cardiotrophin-1 (CT-1), a cytokine related to ciliary neurotrophic factor (CNTF), is expressed at high levels in embryonic limb bud and is secreted by differentiated myotubes. In vitro, CT-1 kept 43% of purified E14 rat motoneurons alive for 2 weeks (EC50 = 20 pM). In vivo, CT-1 protected neonatal sciatic motoneurons against the effects of axotomy. CT-1 action on motoneurons was inhibited by phosphatidylinositol-specific phospholipase C (PIPLC), suggesting that CT-1 may act through a GPI-linked component. Since no binding of CT-1 to CNTFR alpha was detected, CT-1 may use a novel cytokine receptor alpha subunit. CT-1 may be important in normal motoneuron development and as a potential tool for slowing motoneuron degeneration in human diseases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0896-6273
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pubmed:author |
pubmed-author:ArchSS,
pubmed-author:ArmaniniMM,
pubmed-author:DudleyKK,
pubmed-author:HendersonC ECE,
pubmed-author:KatzA HAH,
pubmed-author:PennicaDD,
pubmed-author:PhillipsH SHS,
pubmed-author:PollockR ARA,
pubmed-author:RosenthalAA,
pubmed-author:SwansonT ATA,
pubmed-author:VejsadaRR
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
63-74
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8755479-Animals,
pubmed-meshheading:8755479-Animals, Newborn,
pubmed-meshheading:8755479-Axons,
pubmed-meshheading:8755479-Base Sequence,
pubmed-meshheading:8755479-Cell Survival,
pubmed-meshheading:8755479-Cytokines,
pubmed-meshheading:8755479-Denervation,
pubmed-meshheading:8755479-Embryo, Mammalian,
pubmed-meshheading:8755479-Mice,
pubmed-meshheading:8755479-Molecular Probes,
pubmed-meshheading:8755479-Molecular Sequence Data,
pubmed-meshheading:8755479-Motor Neurons,
pubmed-meshheading:8755479-Muscles,
pubmed-meshheading:8755479-RNA, Messenger,
pubmed-meshheading:8755479-Rats,
pubmed-meshheading:8755479-Receptor, Ciliary Neurotrophic Factor,
pubmed-meshheading:8755479-Receptors, Nerve Growth Factor,
pubmed-meshheading:8755479-Spinal Cord,
pubmed-meshheading:8755479-Time Factors
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pubmed:year |
1996
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pubmed:articleTitle |
Cardiotrophin-1, a cytokine present in embryonic muscle, supports long-term survival of spinal motoneurons.
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pubmed:affiliation |
Department of Molecular Biology, Genentech Incorporated, South San Francisco, California 94080, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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