Linked Life Data

8754210

Source:http://linkedlifedata.com/resource/pubmed/id/8754210

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pubmed-article:8754210pubmed:abstractTextRecent studies of mitochondrial DNA (mtDNA) variation in mammals and Drosophila have shown an excess of amino acid variation within species (replacement polymorphism) relative to the number of silent and replacement differences fixed between species. To examine further this pattern of nonneutral mtDNA evolution, we present sequence data for the ND3 and ND5 genes from 59 lines of Drosophila melanogaster and 29 lines of D. simulans. Of interest are the frequency spectra of silent and replacement polymorphisms, and potential variation among genes and taxa in the departures from neutral expectations. The Drosophila ND3 and ND5 data show no significant excess of replacement polymorphism using the McDonald-Kreitman test. These data are in contrast to significant departures from neutrality for the ND3 gene in mammals and other genes in Drosophila mtDNA (cytochrome b and ATPase 6). Pooled across genes, however, both Drosophila and human mtDNA show very significant excesses of amino acid polymorphism. Silent polymorphisms at ND5 show a significantly higher variance in frequency than replacement polymorphisms, and the latter show a significant skew toward low frequencies (Tajima's D = -1.954). These patterns are interpreted in light of the nearly neutral theory where mildly deleterious amino acid haplotypes are observed as ephemeral variants within species but do not contribute to divergence. The patterns of polymorphism and divergence at charge-altering amino acid sites are presented for the Drosophila ND5 gene to examine the evolution of functionally distinct mutations. Excess charge-altering polymorphism is observed at the carboxyl terminal and excess charge-altering divergence is detected at the amino terminal. While the mildly deleterious model fits as a net effect in the evolution of nonrecombining mitochondrial genomes, these data suggest that opposing evolutionary pressures may act on different regions of mitochondrial genes and genomes.lld:pubmed
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pubmed-article:8754210pubmed:authorpubmed-author:SHAWH WHWlld:pubmed
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pubmed-article:8754210pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:8754210pubmed:articleTitleExcess amino acid polymorphism in mitochondrial DNA: contrasts among genes from Drosophila, mice, and humans.lld:pubmed
pubmed-article:8754210pubmed:affiliationDepartment of Ecology and Evolutionary Biology, Brown University.lld:pubmed
pubmed-article:8754210pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8754210pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:8754210pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
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