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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1996-10-8
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pubmed:databankReference |
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pubmed:abstractText |
A cosmid containing the human NKG2A gene was isolated. The gene was partially sequenced, revealing 7 exons, including one 5' untranslated exon. The 54 base pair exon 5 was missing in the published cDNA clone NKG2B, consistent with the existence of differential splicing. This was confirmed by reverse transcription-polymerase chain reaction of total RNA from normal lymphocytes. The NKG2A gene was mapped by FISH to chromosome 12p12. 3-p13.1 in proximity to the CD69 and Prp genes. These data support the presence of a human lectin-like NK gene complex, analogous to the NK complex on mouse chromosome 6.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0093-7711
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
286-91
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pubmed:dateRevised |
2006-4-13
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pubmed:meshHeading |
pubmed-meshheading:8753859-Alternative Splicing,
pubmed-meshheading:8753859-Amino Acid Sequence,
pubmed-meshheading:8753859-Animals,
pubmed-meshheading:8753859-Base Sequence,
pubmed-meshheading:8753859-Chromosome Mapping,
pubmed-meshheading:8753859-Chromosomes, Artificial, Yeast,
pubmed-meshheading:8753859-Chromosomes, Human, Pair 12,
pubmed-meshheading:8753859-Cosmids,
pubmed-meshheading:8753859-DNA, Complementary,
pubmed-meshheading:8753859-Exons,
pubmed-meshheading:8753859-Humans,
pubmed-meshheading:8753859-In Situ Hybridization, Fluorescence,
pubmed-meshheading:8753859-Killer Cells, Natural,
pubmed-meshheading:8753859-Mice,
pubmed-meshheading:8753859-Molecular Sequence Data,
pubmed-meshheading:8753859-Polymerase Chain Reaction
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pubmed:year |
1996
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pubmed:articleTitle |
Genomic structure, chromosome location, and alternative splicing of the human NKG2A gene.
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pubmed:affiliation |
Human Immunogenetics Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, England.
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pubmed:publicationType |
Journal Article
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