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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
|
pubmed:dateCreated |
1996-10-16
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pubmed:abstractText |
Technetium-99m hexakis-2-methoxyisobutylisonitrile (MIBI) and thallium-201 imaging was performed in a patient with metastatic renal cell carcinoma (RCC), which is a well-known tumour type demonstrating P1-glycoprotein (PGP) overexpression. Two scintigraphic patterns - Tl(+)/MIBI(-) in primary tumour and Tl(+)/MIBI(+) in metastatic tumour - were observed, suggesting high- and low-level PGP expression, respectively. Immunochemical study for PGP revealed strong staining of the primary tumour cells. This case clinically validates the previously suggested relationship between 99mTc-MIBI uptake and PGP expression.
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pubmed:commentsCorrections | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0340-6997
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
23
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
976-9
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:8753689-Aged,
pubmed-meshheading:8753689-Carcinoma, Renal Cell,
pubmed-meshheading:8753689-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:8753689-Humans,
pubmed-meshheading:8753689-Kidney Neoplasms,
pubmed-meshheading:8753689-Lung Neoplasms,
pubmed-meshheading:8753689-Male,
pubmed-meshheading:8753689-P-Glycoprotein,
pubmed-meshheading:8753689-Technetium Tc 99m Sestamibi,
pubmed-meshheading:8753689-Thallium Radioisotopes
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pubmed:year |
1996
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pubmed:articleTitle |
99mTc-MIBI scintigraphy in metastatic renal cell carcinoma: clinical validation of the relationship between 99mTc-MIBI uptake and P-glycoprotein expression in tumour tissue.
|
pubmed:affiliation |
Department of Nuclear Medicine, School of Medicine, Dokuz Eylül University, Izmir, Turkey.
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pubmed:publicationType |
Journal Article,
Case Reports
|