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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1996-10-3
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pubmed:abstractText |
alpha(1,3)Fucosylated oligosaccharides represent components of leukocyte counterreceptors for E- and P-selectins and of L-selectin ligands expressed by lymph node high endothelial venules (HEV). The identity of the alpha(1,3)fucosyltransferase(s) required for their expression has been uncertain, as has a requirement for alpha(1,3)fucosylation in HEV L-selectin ligand activity. We demonstrate here that mice deficient in alpha(1,3) fucosyltransferase Fuc-TVII exhibit a leukocyte adhesion deficiency characterized by absent leukocyte E- and P-selectin ligand activity and deficient HEV L-selectin ligand activity. Selectin ligand deficiency is distinguished by blood leukocytosis, impaired leukocyte extravasation in inflammation, and faulty lymphocyte homing. These observations demonstrate an essential role for Fuc-TVII in E-, P-, and L-selectin ligand biosynthesis and imply that this locus can control leukocyte trafficking in health and disease.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0092-8674
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pubmed:author |
pubmed-author:CamperS ASA,
pubmed-author:CamphausenR TRT,
pubmed-author:ChengGG,
pubmed-author:GerstenK MKM,
pubmed-author:HindsgaulOO,
pubmed-author:IsogaiYY,
pubmed-author:LINSKJJ,
pubmed-author:LoweJ BJB,
pubmed-author:MalýPP,
pubmed-author:MarksR MRM,
pubmed-author:PetryniakBB,
pubmed-author:RogersC ECE,
pubmed-author:SaundersT LTL,
pubmed-author:SmithP LPL,
pubmed-author:SullivanF XFX,
pubmed-author:ThaleJJ,
pubmed-author:von AndrianU HUH
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
643-53
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8752218-Animals,
pubmed-meshheading:8752218-Antigens, Surface,
pubmed-meshheading:8752218-Cell Adhesion,
pubmed-meshheading:8752218-Cell Movement,
pubmed-meshheading:8752218-Cells, Cultured,
pubmed-meshheading:8752218-E-Selectin,
pubmed-meshheading:8752218-Endothelium, Vascular,
pubmed-meshheading:8752218-Fucosyltransferases,
pubmed-meshheading:8752218-Glycosylation,
pubmed-meshheading:8752218-Immunologic Techniques,
pubmed-meshheading:8752218-L-Selectin,
pubmed-meshheading:8752218-Leukocytosis,
pubmed-meshheading:8752218-Ligands,
pubmed-meshheading:8752218-Lymphocytes,
pubmed-meshheading:8752218-Mice,
pubmed-meshheading:8752218-Mice, Knockout,
pubmed-meshheading:8752218-Neutrophils,
pubmed-meshheading:8752218-P-Selectin,
pubmed-meshheading:8752218-Protein Processing, Post-Translational
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pubmed:year |
1996
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pubmed:articleTitle |
The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis.
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pubmed:affiliation |
Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor 48109-0650, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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