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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1996-9-30
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pubmed:abstractText |
Alterations in the cellular redox state play a critical role in cell signaling and cell activation, suggesting that administration of sulfhydryl-reactive agents may have important modulatory effects on the inflammatory response. We postulated that intracellular thiol depletion may attenuate the pulmonary inflammatory response after intratracheal administration of endotoxin (LPS) and that this attenuation would supersede the reduction in antioxidant defenses associated with depletion of the endogenous antioxidant, glutathione.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Aug
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|
pubmed:issn |
0039-6060
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
120
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|
pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
360-6
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8751605-Albumins,
pubmed-meshheading:8751605-Animals,
pubmed-meshheading:8751605-Capillaries,
pubmed-meshheading:8751605-Cell Adhesion,
pubmed-meshheading:8751605-Cell Movement,
pubmed-meshheading:8751605-Cytokines,
pubmed-meshheading:8751605-Endothelium, Vascular,
pubmed-meshheading:8751605-Endotoxins,
pubmed-meshheading:8751605-Escherichia coli,
pubmed-meshheading:8751605-Glutathione,
pubmed-meshheading:8751605-Lipopolysaccharides,
pubmed-meshheading:8751605-Lung,
pubmed-meshheading:8751605-Male,
pubmed-meshheading:8751605-Maleates,
pubmed-meshheading:8751605-Neutrophils,
pubmed-meshheading:8751605-Oxidative Stress,
pubmed-meshheading:8751605-Rats,
pubmed-meshheading:8751605-Rats, Sprague-Dawley,
pubmed-meshheading:8751605-Respiratory Distress Syndrome, Adult
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pubmed:year |
1996
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|
pubmed:articleTitle |
Diethylmaleate attenuates endotoxin-induced lung injury.
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pubmed:affiliation |
Department of Surgery, Toronto Hospital Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
