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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1996-9-27
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pubmed:abstractText |
Cryptic t(12;21)(p12-13;q22) leading to TEL-AML1 fusion has recently been recognized as the most frequent genetic rearrangement in childhood acute lymphoblastic leukemia (ALL) in Western countries. More recently, we found a similar frequency of this abnormality in Chinese children with ALL in Taiwan. In this study, we assessed further the frequency of TEL-AML1 fusion as well as that of BCR-ABL in Chinese adults with ALL, using reverse transcriptase-polymerase chain reaction assays. Among the 81 cases with newly diagnosed B lineage ALL studied, none had the TEL-AML1 fusion whereas 30 had the BCR-ABL fusion. The lack of cases with the TEL-AML1 fusion together with the high frequency of BCR-ABL fusion could largely account for the poorer outcome of adult ALL as compared with childhood ALL.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Core Binding Factor Alpha 2 Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ETS translocation variant 6 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-ets,
http://linkedlifedata.com/resource/pubmed/chemical/RUNX1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0887-6924
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1456-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8751462-Adolescent,
pubmed-meshheading:8751462-Adult,
pubmed-meshheading:8751462-Aged,
pubmed-meshheading:8751462-Aged, 80 and over,
pubmed-meshheading:8751462-Base Sequence,
pubmed-meshheading:8751462-Chromosomes, Human, Pair 12,
pubmed-meshheading:8751462-Chromosomes, Human, Pair 21,
pubmed-meshheading:8751462-Core Binding Factor Alpha 2 Subunit,
pubmed-meshheading:8751462-DNA-Binding Proteins,
pubmed-meshheading:8751462-Female,
pubmed-meshheading:8751462-Humans,
pubmed-meshheading:8751462-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:8751462-Male,
pubmed-meshheading:8751462-Middle Aged,
pubmed-meshheading:8751462-Molecular Sequence Data,
pubmed-meshheading:8751462-Neoplasm Proteins,
pubmed-meshheading:8751462-Oncogene Proteins, Fusion,
pubmed-meshheading:8751462-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:8751462-Proto-Oncogene Proteins,
pubmed-meshheading:8751462-Proto-Oncogene Proteins c-ets,
pubmed-meshheading:8751462-Repressor Proteins,
pubmed-meshheading:8751462-Transcription Factors,
pubmed-meshheading:8751462-Translocation, Genetic
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pubmed:year |
1996
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pubmed:articleTitle |
Lack of TEL-AML1 fusion transcript resulting from a cryptic t(12;21) in adult B lineage acute lymphoblastic leukemia in Taiwan.
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pubmed:affiliation |
Division of Hematology-Oncology, Chang Gung Memorial Hospital, Taipei, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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