Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1996-10-18
|
| pubmed:abstractText |
An immunohistochemical determination of the growth fraction (GF) with the Ki-67 monoclonal antibody has been performed in a prospective series of 140 patients with primary operable breast carcinoma. GF ranged from 0% to 43% Ki-67 stained cells with a median value of 8%. High GF (> 8%) was significantly associated with axillary node involvement (p = 0.006), aneuploidy (p = 0.008), histologic grade (p = 0.03), and S-phase fraction > 5% determined by flow cytometry (p = 0.01). After a median follow-up of 6 years, the univariate analysis did not show significant correlation between high GF and worse relapse-free survival (p = 0.10) or shorter overall survival. However, a multivariate analysis on relapse-free survival, performed in 127 comparable patients, showed that GF was an independent predictive factor (p = 0.03) together with nodal status (p = 0.00001), age under 45 years (p = 0.0008), and chemotherapy (0.006). In node negative patients, GF was still an independent prognostic indicator (p = 0.002) together with age under 45 years (p = 0.0003). Tumor proliferative activity evaluated by the monoclonal antibody Ki-67 appears to be an effective indicator of prognosis in breast cancer and could be of assistance in the decision making of adjuvant therapy in node negative patients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0167-6806
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
37
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
57-64
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8750528-Adult,
pubmed-meshheading:8750528-Aged,
pubmed-meshheading:8750528-Aged, 80 and over,
pubmed-meshheading:8750528-Breast Neoplasms,
pubmed-meshheading:8750528-Cell Division,
pubmed-meshheading:8750528-Female,
pubmed-meshheading:8750528-Follow-Up Studies,
pubmed-meshheading:8750528-Humans,
pubmed-meshheading:8750528-Ki-67 Antigen,
pubmed-meshheading:8750528-Middle Aged,
pubmed-meshheading:8750528-Multivariate Analysis,
pubmed-meshheading:8750528-Neoplasm Proteins,
pubmed-meshheading:8750528-Nuclear Proteins,
pubmed-meshheading:8750528-Prognosis,
pubmed-meshheading:8750528-Prospective Studies,
pubmed-meshheading:8750528-S Phase,
pubmed-meshheading:8750528-Staining and Labeling,
pubmed-meshheading:8750528-Survival Rate
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Long term prognostic value of growth fraction determination by Ki-67 immunostaining in primary operable breast cancer.
|
| pubmed:affiliation |
Laboratoire de Transfert, Institut Curie, Paris, France.
|
| pubmed:publicationType |
Journal Article
|