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pubmed-article:8750203pubmed:abstractTextLong chain alkylcobalamins and long chain acyl-cyanocobalamins, two types of hydrophobic derivatives of vitamin B12, were synthesized. It was shown by TLC and determination of the partition coefficient between organic and aqueous phases that the hydrophobicity of alkylcobalamins and acyl-cyanocobalamins increased with the chain length of the alkyl or acyl group introduced into cobalamin. Long chain alkylcobalamins were easily converted to aquacobalamin by photoirradiation, but the first-order rate constant of photolysis decreased with the length of an alkyl group. Long chain acyl-cyanocobalamins were gradually hydrolyzed to cyanocobalamin in neutral or alkaline solution with the pseudo-first order rate constant increasing with the pH of the solution. Stabilization of acyl-cyanocobalamins toward hydrolysis was achieved by introducing a methyl group into the alpha-position of an acyl group. All the long chain alkylcobalamins tested supported the growth of Escherichia coli 215, a cobalamin- or L-methionine-auxotroph, and Lactobacillus leichmannii, although their activity as cobalamin was at most 28% and 15% that of cyanocobalamin for E. coli 215 and L. leichmannii, respectively.lld:pubmed
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pubmed-article:8750203pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:8750203pubmed:articleTitleSynthesis, properties and microbiological activity of hydrophobic derivatives of vitamin B12.lld:pubmed
pubmed-article:8750203pubmed:affiliationDepartment of Biotechnology, Faculty of Engineering, Okayama University, Japan.lld:pubmed
pubmed-article:8750203pubmed:publicationTypeJournal Articlelld:pubmed