Linked Life Data

8748102

Source:http://linkedlifedata.com/resource/pubmed/id/8748102

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1996-10-23
pubmed:abstractText
Fas is a 43 kDa glycoprotein molecule which is involved in inducing apoptosis in both B and T lymphocytes. In the murine MRL/Ipr-Ipr model of systemic lupus erythematosus (SLE), the lymphoproliferation (lpr) mutation results in defective transcription of the gene that codes for the Fas protein. MRL mice which carry the homozygous recessive Ipr mutation develop a severe early-onset genetically predetermined autoimmune syndrome characterised by high IgG and autoantibody levels and a diffuse proliferative immune complex-mediated glomerulonephritis. Interest in the importance of Fas in SLE has risen with the observation that 60% of human subjects with lupus have elevated levels of the soluble Fas receptor in their serum and that the abnormal presence of this molecule may protect lymphocytes from undergoing apoptosis. In this review the importance of Fas in autoimmune pathogenesis is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0035-8819
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
475-8
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Lupus in the Fas lane?
pubmed:affiliation
New England Medical Center and Tufts University School of Medicine, Boston, MA, USA.
pubmed:publicationType
Journal Article, Review