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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1996-12-12
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pubmed:abstractText |
An CD11a/CD18-dependent homotypic aggregation pathway is induced by triggering CD45 molecules on human thymocytes. By contrast, a CD11a/CD18-independent homotypic aggregation process is induced by triggering the CD99 molecule (E2, MIC2 gene product) expressed at the surface of either Jurkat T cells or human thymocytes. A new quantitative method based on FACS analysis of aggregated cells was used and allowed to show that both types of aggregation (CD11a/CD18-dependent and CD11a/CD18-independent) were inhibited with sphingosine, oleylamine or stearylamine. These three compounds had no effect on the expression of CD99, CD45, CD11a, CD18 or other [correction of others] known integrins expressed at the surface of the cells studied.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amines,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD18,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/CD99 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Integrins,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Function-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Sphingosine,
http://linkedlifedata.com/resource/pubmed/chemical/oleylamine,
http://linkedlifedata.com/resource/pubmed/chemical/stearylamine
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0165-2478
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
175-80
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pubmed:dateRevised |
2010-9-1
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pubmed:meshHeading |
pubmed-meshheading:8747715-Amines,
pubmed-meshheading:8747715-Antigens, CD,
pubmed-meshheading:8747715-Antigens, CD18,
pubmed-meshheading:8747715-Antigens, CD45,
pubmed-meshheading:8747715-Cell Adhesion Molecules,
pubmed-meshheading:8747715-Cell Aggregation,
pubmed-meshheading:8747715-Cell Line,
pubmed-meshheading:8747715-Child, Preschool,
pubmed-meshheading:8747715-Dose-Response Relationship, Drug,
pubmed-meshheading:8747715-Flow Cytometry,
pubmed-meshheading:8747715-Humans,
pubmed-meshheading:8747715-Infant,
pubmed-meshheading:8747715-Infant, Newborn,
pubmed-meshheading:8747715-Integrins,
pubmed-meshheading:8747715-Kinetics,
pubmed-meshheading:8747715-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:8747715-Sphingosine,
pubmed-meshheading:8747715-T-Lymphocytes,
pubmed-meshheading:8747715-Thymus Gland
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pubmed:year |
1995
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pubmed:articleTitle |
Sphingosine, oleylamine and stearylamine inhibit both CD11a/CD18-dependent and -independent homotypic aggregation: demonstration by cytofluorimetry.
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pubmed:affiliation |
INSERM U343, Hôpital de l'Archet, BP. 79, 06202 Nice, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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