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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1996-10-24
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pubmed:abstractText |
The Charcot-Leyden crystal (CLC) protein is a major autocrystallizing constituent of human eosinophils and basophils, comprising approximately 10% of the total cellular protein in these granulocytes. Identification of the distinctive hexagonal bipyramidal crystals of CLC protein in body fluids and secretions has long been considered a hallmark of eosinophil-associated allergic inflammation. Although CLC protein possesses lysophospholipase activity, its role(s) in eosinophil or basophil function or associated inflammatory responses has remained speculative.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0969-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1379-93
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8747464-Acute Disease,
pubmed-meshheading:8747464-Amino Acid Sequence,
pubmed-meshheading:8747464-Base Sequence,
pubmed-meshheading:8747464-Binding Sites,
pubmed-meshheading:8747464-Carbohydrate Metabolism,
pubmed-meshheading:8747464-Chromatography, Affinity,
pubmed-meshheading:8747464-Crystallography, X-Ray,
pubmed-meshheading:8747464-Eosinophils,
pubmed-meshheading:8747464-Galectin 1,
pubmed-meshheading:8747464-Galectin 2,
pubmed-meshheading:8747464-Glycoproteins,
pubmed-meshheading:8747464-Hemagglutinins,
pubmed-meshheading:8747464-Humans,
pubmed-meshheading:8747464-Lectins,
pubmed-meshheading:8747464-Leukemia, Myeloid,
pubmed-meshheading:8747464-Lysophospholipase,
pubmed-meshheading:8747464-Models, Molecular,
pubmed-meshheading:8747464-Multigene Family,
pubmed-meshheading:8747464-Neoplasm Proteins,
pubmed-meshheading:8747464-Protein Conformation,
pubmed-meshheading:8747464-Sequence Alignment,
pubmed-meshheading:8747464-Sequence Homology, Amino Acid,
pubmed-meshheading:8747464-Tumor Cells, Cultured
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pubmed:year |
1995
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pubmed:articleTitle |
Crystal structure of human Charcot-Leyden crystal protein, an eosinophil lysophospholipase, identifies it as a new member of the carbohydrate-binding family of galectins.
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pubmed:affiliation |
School of Biology and Biochemistry, University of Bath, Claverton Down, UK.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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