Linked Life Data

8746983

Source:http://linkedlifedata.com/resource/pubmed/id/8746983

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1996-10-9
pubmed:abstractText
1. The effects of corticosterone and the time of its addition to cultures, on concanavalin A (Con-A) and pokeweed mitogen (PWM)-induced lymphocyte proliferation were studied. 2. Peripheral blood lymphocytes (PBL) were isolated from Cornell K-strain Single Comb White Leghorn immature male chickens and cultured with various concentrations of Con-A or PWM. Corticosterone, in different concentrations, was added to the cultures either 2 h before or 2 h after the addition of the respective mitogen. 3. Addition of corticosterone 2 h before the mitogens caused a significant suppression of lymphocyte proliferation in response to both Con-A and PWM stimulation. Also addition of corticosterone 2 h after the mitogens caused significant suppression of proliferation in response to both mitogens; however, the degree of suppression was not as great. 4. The results indicate that after early activation events are initiated by the mitogens, lymphocytes are less sensitive to the effects of corticosterone. Because less suppression was seen in the cultures preincubated with PWM than those with Con-A, it is likely that there are different sensitivities to corticosterone in the cell populations that respond to these mitogens.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0007-1668
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
813-20
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Effects of in vitro corticosterone on chicken T- and B-lymphocyte proliferation.
pubmed:affiliation
Department of Poultry Science, Pennsylvania State University, University Park 16802, USA.
pubmed:publicationType
Journal Article