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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1997-2-12
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pubmed:abstractText |
Major histocompatibility (MHC) class I gene expression is synergistically induced by the cytokines TNF-alpha and IFN-gamma. However, the mechanism that results in synergistic activation of these genes has remained unclear. We demonstrated here that TNF-alpha induced binding of NF kappa B p50 and p65 to the NF kappa B-like element of the MHC class I promoter termed region I and IFN-gamma induced binding of IRF-1 to the adjacent interferon consensus sequence (ICS). We further demonstrated that NF kappa B and IRF-1 physically interacted with each other and cooperatively induced MHC class I gene expression when cotransfected into CHP-126 neuroblastomas. These results provide a molecular mechanism by which TNF-alpha and IFN-gamma synergistically induce the expression of a variety of genes involved in immune responses, including MHC class I.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1079-9907
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1037-45
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8746784-Base Sequence,
pubmed-meshheading:8746784-Consensus Sequence,
pubmed-meshheading:8746784-DNA-Binding Proteins,
pubmed-meshheading:8746784-Drug Synergism,
pubmed-meshheading:8746784-Gene Expression Regulation,
pubmed-meshheading:8746784-Genes, MHC Class I,
pubmed-meshheading:8746784-Genetic Vectors,
pubmed-meshheading:8746784-Humans,
pubmed-meshheading:8746784-Interferon Regulatory Factor-1,
pubmed-meshheading:8746784-Interferon-gamma,
pubmed-meshheading:8746784-Molecular Sequence Data,
pubmed-meshheading:8746784-NF-kappa B,
pubmed-meshheading:8746784-Phosphoproteins,
pubmed-meshheading:8746784-Promoter Regions, Genetic,
pubmed-meshheading:8746784-Stimulation, Chemical,
pubmed-meshheading:8746784-Transcription Factors,
pubmed-meshheading:8746784-Tumor Cells, Cultured,
pubmed-meshheading:8746784-Tumor Necrosis Factor-alpha
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pubmed:year |
1995
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pubmed:articleTitle |
NF kappa B and interferon regulatory factor 1 physically interact and synergistically induce major histocompatibility class I gene expression.
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pubmed:affiliation |
Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article
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