Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-10-11
pubmed:abstractText
Peptidylglycine alpha-amidating monooxygenase (PAM), the enzyme responsible for the alpha-amidation of neuroendocrine peptides, is more prevalent in the atrium of the heart than in pituitary or brain. RNase protection assays indicate that PAM transcripts account for approximately 0.5% of the mRNA in the neonatal atrium and 0.06% of the mRNA in the neonatal ventricle. In primary atrial cardiomyocyte cultures PAM mRNA turns over slowly, with a half-life of approximately 20 h. Levels of PAM mRNA in primary atrial cardiomyocytes are increased to 16.5% of control upon treatment with dexamethasone and decreased to 63% of control upon treatment with thyroid hormone.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-2828
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
155-63
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:8745223-Animals, pubmed-meshheading:8745223-Animals, Newborn, pubmed-meshheading:8745223-Antisense Elements (Genetics), pubmed-meshheading:8745223-Brain, pubmed-meshheading:8745223-Cells, Cultured, pubmed-meshheading:8745223-Dexamethasone, pubmed-meshheading:8745223-Gene Expression Regulation, Enzymologic, pubmed-meshheading:8745223-Heart Atria, pubmed-meshheading:8745223-Heart Ventricles, pubmed-meshheading:8745223-Kinetics, pubmed-meshheading:8745223-Mixed Function Oxygenases, pubmed-meshheading:8745223-Multienzyme Complexes, pubmed-meshheading:8745223-Myocardium, pubmed-meshheading:8745223-Organ Specificity, pubmed-meshheading:8745223-Pituitary Gland, pubmed-meshheading:8745223-RNA, Messenger, pubmed-meshheading:8745223-Rats, pubmed-meshheading:8745223-Rats, Sprague-Dawley, pubmed-meshheading:8745223-Transcription, Genetic, pubmed-meshheading:8745223-Triiodothyronine
pubmed:year
1996
pubmed:articleTitle
Prevalence and turnover of peptidylglycine alpha-amidating monooxygenase mRNA in atrial cardiomyocytes.
pubmed:affiliation
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore MD 21205, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.