rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1996-10-11
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pubmed:abstractText |
Peptidylglycine alpha-amidating monooxygenase (PAM), the enzyme responsible for the alpha-amidation of neuroendocrine peptides, is more prevalent in the atrium of the heart than in pituitary or brain. RNase protection assays indicate that PAM transcripts account for approximately 0.5% of the mRNA in the neonatal atrium and 0.06% of the mRNA in the neonatal ventricle. In primary atrial cardiomyocyte cultures PAM mRNA turns over slowly, with a half-life of approximately 20 h. Levels of PAM mRNA in primary atrial cardiomyocytes are increased to 16.5% of control upon treatment with dexamethasone and decreased to 63% of control upon treatment with thyroid hormone.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-2828
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
155-63
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8745223-Animals,
pubmed-meshheading:8745223-Animals, Newborn,
pubmed-meshheading:8745223-Antisense Elements (Genetics),
pubmed-meshheading:8745223-Brain,
pubmed-meshheading:8745223-Cells, Cultured,
pubmed-meshheading:8745223-Dexamethasone,
pubmed-meshheading:8745223-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:8745223-Heart Atria,
pubmed-meshheading:8745223-Heart Ventricles,
pubmed-meshheading:8745223-Kinetics,
pubmed-meshheading:8745223-Mixed Function Oxygenases,
pubmed-meshheading:8745223-Multienzyme Complexes,
pubmed-meshheading:8745223-Myocardium,
pubmed-meshheading:8745223-Organ Specificity,
pubmed-meshheading:8745223-Pituitary Gland,
pubmed-meshheading:8745223-RNA, Messenger,
pubmed-meshheading:8745223-Rats,
pubmed-meshheading:8745223-Rats, Sprague-Dawley,
pubmed-meshheading:8745223-Transcription, Genetic,
pubmed-meshheading:8745223-Triiodothyronine
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pubmed:year |
1996
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pubmed:articleTitle |
Prevalence and turnover of peptidylglycine alpha-amidating monooxygenase mRNA in atrial cardiomyocytes.
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pubmed:affiliation |
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore MD 21205, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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