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rdf:type |
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lifeskim:mentions |
umls-concept:C0002518,
umls-concept:C0018183,
umls-concept:C0033684,
umls-concept:C0079189,
umls-concept:C0086418,
umls-concept:C0619961,
umls-concept:C0728938,
umls-concept:C1280500,
umls-concept:C1524119,
umls-concept:C1539788,
umls-concept:C1706793,
umls-concept:C1710548
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pubmed:issue |
1
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pubmed:dateCreated |
1996-10-11
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pubmed:abstractText |
The N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP), a unique cytokine present in human granulocytes, was determined to be: Pyroglu-Leu-Lys-X-Tyr-Thr-X-Lys-Glu-Pro-Met-Thr-Ser(Thr)-Ala-Ala... This sequence showed no significant homology with any other protein when used in database searches. Furthermore, a synthetic nonapeptide corresponding to the first nine residues, with Cys in positions 4 and 7, was found to be a biologically active in vitro anti-tumour agent. An alternate method for the purification of ANUP to that previously reported is also presented. This method involves differential Amicon Diaflo membrane filtration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ARS protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Ly,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Leucyl Aminopeptidase,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Pyroglutamyl-Peptidase I,
http://linkedlifedata.com/resource/pubmed/chemical/Urokinase-Type Plasminogen Activator
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1043-4666
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8742060-Amino Acid Sequence,
pubmed-meshheading:8742060-Antigens, Ly,
pubmed-meshheading:8742060-Antineoplastic Agents,
pubmed-meshheading:8742060-Cell Survival,
pubmed-meshheading:8742060-Cytokines,
pubmed-meshheading:8742060-Granulocytes,
pubmed-meshheading:8742060-HeLa Cells,
pubmed-meshheading:8742060-Humans,
pubmed-meshheading:8742060-Leucyl Aminopeptidase,
pubmed-meshheading:8742060-Male,
pubmed-meshheading:8742060-Molecular Sequence Data,
pubmed-meshheading:8742060-Peptide Fragments,
pubmed-meshheading:8742060-Proteins,
pubmed-meshheading:8742060-Pyroglutamyl-Peptidase I,
pubmed-meshheading:8742060-Sequence Homology, Amino Acid,
pubmed-meshheading:8742060-Tumor Cells, Cultured,
pubmed-meshheading:8742060-Ultrafiltration,
pubmed-meshheading:8742060-Urokinase-Type Plasminogen Activator
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pubmed:year |
1996
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pubmed:articleTitle |
Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes.
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pubmed:affiliation |
Woods Hole Oceanographic Institution, Massachusetts, 02543, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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