Linked Life Data

874074

Source:http://linkedlifedata.com/resource/pubmed/id/874074

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1977-8-12
pubmed:abstractText
Arachidonic acid is unique amongst human platelet fatty acids in that it is the precursor of prostaglandins and thromboxanes. Since a number of these oxygenated products of arachidonic acid have potent effects on platelet function, an understanding of the metabolsim of their precursor is important. Human platelets have a mechanism for incorporating arachidonic acid from plasma into their phospholipids and, in response to thrombin, they reveal mechanisms for hydrolyzing this arachidonic acid from platelet phosphatidylcholine and phosphatidylinositol. This report deals with the specificity of these mechanisms. The present studies show that human platelets contain phospholipase A2 activities that preferentially release arachidonic acid. One of these activities specifically utilizes 1-acyl-2-arachidonyl-phosphatidyl-choline. Another utilizes platelet phosphatidylinositol and/or phosphatidylserine, both of which are highly enriched with arachidonic acid.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/874074-1059088, http://linkedlifedata.com/resource/pubmed/commentcorrection/874074-1137713, http://linkedlifedata.com/resource/pubmed/commentcorrection/874074-1252495, http://linkedlifedata.com/resource/pubmed/commentcorrection/874074-13817285, http://linkedlifedata.com/resource/pubmed/commentcorrection/874074-4364319, http://linkedlifedata.com/resource/pubmed/commentcorrection/874074-4439372, http://linkedlifedata.com/resource/pubmed/commentcorrection/874074-4462154, http://linkedlifedata.com/resource/pubmed/commentcorrection/874074-4471695, http://linkedlifedata.com/resource/pubmed/commentcorrection/874074-4521806, http://linkedlifedata.com/resource/pubmed/commentcorrection/874074-5114996, http://linkedlifedata.com/resource/pubmed/commentcorrection/874074-5346409, http://linkedlifedata.com/resource/pubmed/commentcorrection/874074-5660093, http://linkedlifedata.com/resource/pubmed/commentcorrection/874074-5764109
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Selective release of archidonic acid from the phospholipids of human platelets in response to thrombin.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.