Linked Life Data

8740506

Source:http://linkedlifedata.com/resource/pubmed/id/8740506

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-3-19
pubmed:abstractText
OBJECTIVE: To review the clinical assessment of iron deficiency and excess. CONCLUSIONS: Two key iron-related proteins in the human body are ferritin which is the iron storage protein, and the transferrin receptor, which controls the entry of iron-bearing transferrin to cells. Intact ferritin and truncated transferrin-receptor molecules are present in serum in direct quantitative proportion to their total tissue content. Ferritin and transferrin-receptor production are precisely and reciprocally regulated at a posttranscriptional level. This is achieved by an iron-responsive element-binding protein that interacts with iron-responsive elements in the mRNA of each, but with contrary effects. Increases in serum ferritin reflect increased storage iron and increases in serum transferrin receptor reflect cellular iron deficits. The combined use of these two measurements allows accurate definition of the entire range of body iron status. This is valid even in situations where assessment of iron status has been notoriously problematic, including periods of rapid growth, in pregnancy, in conditions associated with inflammation, and in trained athletes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0009-9120
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
209-15
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Assessment of iron status.
pubmed:affiliation
Department of Medicine, University of Kansas Medical Center, Kansas City 66160-7402, USA.
pubmed:publicationType
Journal Article, Review