Linked Life Data

8739844

Source:http://linkedlifedata.com/resource/pubmed/id/8739844

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-3-27
pubmed:abstractText
The preferential dopamine autoreceptor, and slightly D3 preferring, antagonist (+)-UH232 (cis-(+)-(1S,2R)-5-methoxy-1-methyl-2-(n-dipropylamino) tetralin) increases locomotor activity and synaptic dopamine release in the nucleus accumbens and striatum after systemic administration to the rat. As shown in this study, (+)-UH232, was unable to produce an increase in locomotor activity measured for 60 minutes after local administration into the terminal or somato-dendritic regions of the mesolimbic dopamine pathways or into the lateral ventricle. Instead, a dose dependent decrease of spontaneous locomotor activity after local application (0.05-50.0 nmol/side) of (+)-UH232 into the nucleus accumbens, was seen. A similar reduction in locomotor activity was produced by the classical dopamine antagonist raclopride. Analysis of the dose*time interactions on locomotor activity did, however, indicate that there is a significant dose*time interaction after local application of (+)-UH232 into the lateral ventricle and VTA. Raclopride, on the other hand, produced only a weak time dependent effect in the VTA. The potential problem of Leao's spreading depression in micro-injection experiments were considered, however, spreading depression does not seem to influence the effects of (+)-UH232 locally applied into the nucleus accumbens. In conclusion, both (+)-UH232 and raclopride produced a dose dependent decrease in spontaneous locomotor activity when examined as the total activity count over 60 minutes after local application into the N Acc.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-9564
pubmed:author
pubmed:issnType
Print
pubmed:volume
103
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
331-41
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:8739844-8-Hydroxy-2-(di-n-propylamino)tetralin, pubmed-meshheading:8739844-Animals, pubmed-meshheading:8739844-Brain, pubmed-meshheading:8739844-Cortical Spreading Depression, pubmed-meshheading:8739844-Dopamine Antagonists, pubmed-meshheading:8739844-Dose-Response Relationship, Drug, pubmed-meshheading:8739844-Habituation, Psychophysiologic, pubmed-meshheading:8739844-Injections, Intraventricular, pubmed-meshheading:8739844-Male, pubmed-meshheading:8739844-Microinjections, pubmed-meshheading:8739844-Motor Activity, pubmed-meshheading:8739844-Nucleus Accumbens, pubmed-meshheading:8739844-Raclopride, pubmed-meshheading:8739844-Rats, pubmed-meshheading:8739844-Rats, Sprague-Dawley, pubmed-meshheading:8739844-Salicylamides, pubmed-meshheading:8739844-Ventral Tegmental Area
pubmed:year
1996
pubmed:articleTitle
Effects on locomotor activity after local application of (+)-UH232 in discrete areas of the rat brain.
pubmed:affiliation
Department of Pharmacology, University of Göteborg, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't