Linked Life Data

8738261

Source:http://linkedlifedata.com/resource/pubmed/id/8738261

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1996-11-13
pubmed:abstractText
Exposure of rats to 3,3'-iminodipropionitrile (IDPN) results in neurofilament (NF)-filled swellings in the proximal axons of a number of large neurons, including sensory neurons in the dorsal root ganglia (DRG) and motor neurons in the spinal cord. The present report describes the effects of acute and chronic IDPN exposure on the vestibular ganglion (VG) neurons as compared to those on the DRG neurons. In the VG, IDPN induced intra-perikaryal accumulation of morphologically and immunocytochemically identified NFs. In the DRG of the same treated animals, IDPN induced proximal axonal swelling but no perikaryal NF accumulations. We concluded that the VG neurons preferentially express the IDPN-induced NF pathology in their myelinated cell bodies. It is hypothesized that the NF pathology occurring after IDPN is preferentially expressed in myelinated structures.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
717
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
118-26
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
3,3'-Iminodipropionitrile induces neurofilament accumulations in the perikarya of rat vestibular ganglion neurons.
pubmed:affiliation
Department de Farmacologia i Toxicologia, I.I.B.B., C.S.I.C., Barcelona, Spain.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't