Linked Life Data

8738048

Source:http://linkedlifedata.com/resource/pubmed/id/8738048

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-1-28
pubmed:abstractText
A method for the simultaneous determination of HEPP (D,L-3-hydroxy-3-ethyl-3-phenylpropionamide), a member of a new homologous series of phenylamide-derivative anticonvulsants, with six other antiepileptic drugs (ethosuximide, primidone, phenobarbital, phenytoin, carbamazepine and clonazepam) in plasma by high-performance liquid chromatography is described. These drugs are extracted from plasma by adding an equal volume of acetonitrile. An aliquot of the extract is then injected on a reversed-phase column with a acetonitrile-methanol-phosphate buffer mobile phase. The total time required for the whole analytical process, including the plasma pretreatment and chromatography, is approximately 30 min. The assay method is simple, rapid and reproducible, and therefore considered suitable for routine use in clinical investigations monitoring HEPP simultaneously with common antiepileptic drugs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1572-6495
pubmed:author
pubmed:issnType
Print
pubmed:day
12
pubmed:volume
678
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
377-83
pubmed:dateRevised
2007-10-16
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Liquid chromatographic assay in plasma of one of the members of a new series of anticonvulsants: D,L-3-hydroxy-3-ethyl-3-phenylpropionamide.
pubmed:affiliation
Department of Physiology, Biophysics and Neurosciences, Centro de Investigación y de Estudios Avanzados del IPN, Mexico, D.F., Mexico.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't