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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1997-1-28
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pubmed:abstractText |
A high-performance liquid chromatographic method is described for determination of sub-anaesthetic concentrations of the enantiomers of ketamine and its metabolite norketamine in plasma. The samples are purified by reversed-phase solid-phase extraction. The enantiomers are separated on a Chiral AGP column with a mobile phase containing 16% methanol and a 10 mM phosphate buffer at pH 7.0, and measured by UV-detection at a wavelength of 220 nm. Linear calibration curves with correlation coefficients better than 0.995 have been obtained in the range 10-320 ng/ml. Minimum detectable concentrations were about 2 ng/ml.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1572-6495
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
678
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
373-6
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pubmed:dateRevised |
2007-10-16
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pubmed:meshHeading |
pubmed-meshheading:8738047-Anesthetics, Dissociative,
pubmed-meshheading:8738047-Chromatography, High Pressure Liquid,
pubmed-meshheading:8738047-Humans,
pubmed-meshheading:8738047-Ketamine,
pubmed-meshheading:8738047-Methanol,
pubmed-meshheading:8738047-Microchemistry,
pubmed-meshheading:8738047-Stereoisomerism
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pubmed:year |
1996
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pubmed:articleTitle |
Determination of ketamine and norketamine enantiomers in plasma by solid-phase extraction and high-performance liquid chromatography.
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pubmed:affiliation |
Karolinska Institute, Department of Medical Laboratory Sciences & Technology, Huddinge University Hospital, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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