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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1996-10-24
|
| pubmed:abstractText |
The pathophysiological responses to immune stress (IS) include activation of several processes which are dependent on cytosolic Ca2+ elevation. Magnesium frequently acts as a natural Ca2+ antagonist. In this study we have observed that Mg2+ can protect guinea-pigs against IS. Antigen-sensitized guinea-pigs, which had been fed a magnesium-deficient diet, were given a single dose (15 mg) of MgCl2 intraperitoneally 1 h before antigen challenge. The development of anaphylactic shock (AS) was observed during the next 2 h, and the hearts were subsequently examined histologically for signs of cardiac myolysis (CM). Magnesium (i) reduced the incidence of CM from 40% to 10% (p < 0.05); (ii) reduced the incidence of AS from 61% to 35% (p < 0.05); (iii) attenuated the severity of the AS; and (iv) lowered mortality from 39% in the control to 19% in the Mg(2+)-treated group (p = 0.1). Serum and tissue total [Mg2+] were not affected by the administration of MgCl2. Also, the serum and heart Mg2+ levels were the same whether or not the guinea-pigs developed AS or CM. In cell culture we demonstrated that by elevating the [Mg2+] in the medium bathing sensitized rat basophilic leukemia (RBL) cells, the increase in cytosolic [Ca2+] subsequent to antigen challenge was reduced from 174 +/- 23.28% (1 mM) to 82.74 +/- 13.22% (3 mM). We conclude that a single treatment with Mg2+ can considerably diminish damage induced by immune stress, probably by its altering the Ca2+: Mg2+ ratio. Since the physiological reaction to different types of stress is similar, Mg2+ could prove beneficial in preventing stress-induced shock in general. Studies examining the mechanisms by which Mg2+ exerts its effects thus provide a scientific basis for the current clinical use of Mg2+ in acute myocardial infarction (AMI) and asthma.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0792-6855
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
45-58
|
| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:8736070-Anaphylaxis,
pubmed-meshheading:8736070-Animals,
pubmed-meshheading:8736070-Antigens,
pubmed-meshheading:8736070-Calcium,
pubmed-meshheading:8736070-Cytosol,
pubmed-meshheading:8736070-Disease Models, Animal,
pubmed-meshheading:8736070-Guinea Pigs,
pubmed-meshheading:8736070-Heart,
pubmed-meshheading:8736070-Injections, Intraperitoneal,
pubmed-meshheading:8736070-Leukemia, Basophilic, Acute,
pubmed-meshheading:8736070-Magnesium,
pubmed-meshheading:8736070-Magnesium Chloride,
pubmed-meshheading:8736070-Magnesium Deficiency,
pubmed-meshheading:8736070-Male,
pubmed-meshheading:8736070-Myocardial Infarction,
pubmed-meshheading:8736070-Myocardium,
pubmed-meshheading:8736070-Rats,
pubmed-meshheading:8736070-Specific Pathogen-Free Organisms,
pubmed-meshheading:8736070-Tumor Cells, Cultured
|
| pubmed:articleTitle |
Magnesium protects against anaphylactic shock and cardiac myolysis in guinea-pigs.
|
| pubmed:affiliation |
Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|