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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1996-10-24
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pubmed:abstractText |
Levels of nitric oxide synthase (NOS) and NADPH-diaphorase in adrenal glands of streptozotocin-diabetic rats of 8 and 12 weeks' duration compared with control rats were assessed with histo-chemical and biochemical techniques. Adrenal glands from streptozotocin-diabetic rats of 8 weeks' duration treated with ganglioside were examined also. In the adrenal medulla of 8-weeks- and 12-weeks-diabetic rats, NOS-immunoreactive nerve fibres were increased and decreased, respectively; additional NOS-immunoreactive and NADPH-diaphorase stained cells, which appeared to be cortical cells, were located in medulla and cortex compared with controls. Increased intensity in NADPH-diaphorase staining of the cortical cells of diabetic rats was observed also. Ganglioside treatment of the 8-weeks-diabetic rats prevented the diabetic-induced increase in NOS-immunoreactive nerve fibres. Also, it reduced most of the increase in the NOS-immunoreactive and NADPH-diaphorase stained cells and the intensity of NADPH-diaphorase staining of cortical cells. With biochemical assay, a significant increase in NOS activity was found in the adrenal glands from 8-weeks-diabetic rats, and this increase was reduced by ganglioside treatment in four out of six diabetic rats. In summary, streptozotocin-induced diabetes causes an initial increase in the levels of NOS and NADPH-diaphorase in the adrenal gland of rat, which was prevented by ganglioside treatment.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0736-5748
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
111-23
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8735786-Adrenal Cortex,
pubmed-meshheading:8735786-Adrenal Glands,
pubmed-meshheading:8735786-Adrenal Medulla,
pubmed-meshheading:8735786-Animals,
pubmed-meshheading:8735786-Blood Glucose,
pubmed-meshheading:8735786-Body Weight,
pubmed-meshheading:8735786-Diabetes Mellitus, Experimental,
pubmed-meshheading:8735786-Gangliosides,
pubmed-meshheading:8735786-Immunohistochemistry,
pubmed-meshheading:8735786-Male,
pubmed-meshheading:8735786-NADPH Dehydrogenase,
pubmed-meshheading:8735786-Nitric Oxide Synthase,
pubmed-meshheading:8735786-Organ Size,
pubmed-meshheading:8735786-Rats,
pubmed-meshheading:8735786-Rats, Wistar
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pubmed:year |
1996
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pubmed:articleTitle |
Increase in nitric oxide synthase and NADPH-diaphorase in the adrenal gland of streptozotocin-diabetic Wistar rats and its prevention by ganglioside.
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pubmed:affiliation |
Department of Anatomy and Developmental Biology, University College London, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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