Linked Life Data

8734189

Source:http://linkedlifedata.com/resource/pubmed/id/8734189

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-9-23
pubmed:abstractText
Coronary restenosis is the direct result of arterial trauma caused by angioplasty and therefore affects all patients to different degrees. Fracture of the plaque extending to the media is the principal mechanism of increase of the arterial lumen after balloon angioplasty, wall stretching concerning mainly excentric lesions. Atherectomy causes pulverisation of excision of the plaque without fracture. Stents reduce the amount of debris and the torn appearances of the plaque often observed after angioplasty. Four mechanisms are involved in the induction of restenosis: neointimal hyperplasia, proportional to the amount of trauma (damage to the internal elastic layer), related to proliferation of smooth muscle cells migrating from the media to the intima nad stimulated by many growth factors: defective remodelling or chronic elastic recoil, characterised by a reduction of the arterial lumen at the angioplasty site; acute elastic recoil in the first minutes or hours after angioplasty, mainly observed in excentric lesions; thrombosis, whose role is secondary except in certain clinical situations such as unstable angina, angioplasty of saphenous vein grafts or long dissections. The classical theories of restensosis attribute a major role to initial hyperplasia but more recent experimental and clinical data, obtained largely from endocoronary ultrasonography, suggest that defective remodelling may be more important. Although endocoronary stents prevent acute and chronic elastic recoil effectively, they do not prevent restenosis which remains a complex, multifactorial phenomenon.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0003-9683
pubmed:author
pubmed:issnType
Print
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
359-65
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
[Mechanisms of restenosis after coronary angioplasty].
pubmed:affiliation
Service de cardiologie A, hôpital Arnaud-de-Villeneuve, Montpelier.
pubmed:publicationType
Journal Article, English Abstract, Review