Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1996-10-16
|
| pubmed:abstractText |
BACKGROUND AND METHODS: By multivariable analysis, risk factors were identified for initial infection of any type, cumulative infections during the first 6 months and fatal infection among 2210 heart transplant recipients at 30 institutions. RESULTS AND CONCLUSIONS: Of the 1218 infections in 695 patients, bacterial infections were most frequent (47%), followed by viral (42%), fungal (8%), and protozoal (4%). Risk factors for earlier infection included older recipient age (p < 0.0001), ventilator support at time of transplant (p < 0.0001), ventricular assist device at time of transplant (p = 0.02), OKT3 induction therapy (p < 0.0001), donor black race (p = 0.0007), and positive donor cytomegalovirus serology (for cytomegalovirus infection) (p = 0.0007). Cumulative infections during the first 6 months were increased by older recipient age (p < 0.0001), ventilator support at transplant (p = 0.0004), ventricular assist at transplant (p = 0.009), Black donor (p = 0.03), female donor (p = 0.03), and OKT3 induction therapy (p = 0.005). The actuarial freedom from fatal infection was 96% at 1 year and 95% at 3 years. Risk factors for death from infection included very old (p = 0.002) and very young recipients (p = 0.004), ventilator support at time of transplant (p = 0.004), older donor (p < 0.0001), and longer donor ischemic time (p = 0.02). The risk of death from infection within the first 3 months exceeded 20% among older recipients (> 55 years) on ventilator support at time of transplantation who received an older (> 50 years) donor heart.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1053-2498
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
329-41
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8732591-Actuarial Analysis,
pubmed-meshheading:8732591-African Americans,
pubmed-meshheading:8732591-Age Factors,
pubmed-meshheading:8732591-Bacterial Infections,
pubmed-meshheading:8732591-Female,
pubmed-meshheading:8732591-Heart Transplantation,
pubmed-meshheading:8732591-Heart-Assist Devices,
pubmed-meshheading:8732591-Humans,
pubmed-meshheading:8732591-Immunosuppressive Agents,
pubmed-meshheading:8732591-Male,
pubmed-meshheading:8732591-Middle Aged,
pubmed-meshheading:8732591-Muromonab-CD3,
pubmed-meshheading:8732591-Mycoses,
pubmed-meshheading:8732591-Postoperative Complications,
pubmed-meshheading:8732591-Protozoan Infections,
pubmed-meshheading:8732591-Respiration, Artificial,
pubmed-meshheading:8732591-Risk Factors,
pubmed-meshheading:8732591-Sex Factors,
pubmed-meshheading:8732591-Time Factors,
pubmed-meshheading:8732591-Tissue Donors,
pubmed-meshheading:8732591-Virus Diseases
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Risk factors for early, cumulative, and fatal infections after heart transplantation: a multiinstitutional study.
|
| pubmed:affiliation |
Cardiac Transplant Research Database Group, University of Alabama at Birmingham, USA.
|
| pubmed:publicationType |
Journal Article,
Multicenter Study
|