Linked Life Data

8732061

Source:http://linkedlifedata.com/resource/pubmed/id/8732061

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1996-10-10
pubmed:abstractText
The effects of vesnarinone on L-type Ca2+ channel current of embryonic chick ventricular myocytes were studied with cell-attached patch clamp technique. Vesnarinone was used in the concentrations of 10(-5), 2 x 10(-5) and 10(-4) mol/L; the availability (P8) of Ca2+ channel activity was increased (P < 0.001) markedly (about 2-3 fold). The increasing of the open probability (Po) of Ca2+ channel by vesnarinone showed concentration-dependence. The increase was 2.25 (10(-5)mol/L), 3(2 x 10(-5)mol/L) and 4.3(10(-4)mol/L) fold. The open time rate constant (tau 0) and close time rate constant (tau 1 and tau 2) of Ca2+ channel were not changed in the concentrations of 10(-5) and 2 x 10(-5) mol/L, but the tau 0 was slightly decreased in the concentration of 10(-4) mol/L. The actions of vesnarinone on single Ca2+ current were compared with those of milrinone (it is known as an PDE inhibitor which had inotropic effect associated with an increase in cytoplasmic cAMP level.) The effects of milrinone on P8, tau 0 and tau 1 were similar with those of vesnarinone (10(-4) mol/L), but the increase of Po was 2 fold less than that of vesnarinone. The results showed that apart from the role of PDE inhibitor, vesnarinone has other effects on myocytes.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0257-7712
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
403-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
[Effects of vesnarinone on L-type single Ca2+ channel current in cultured ventricular myocytes of embryonic chick].
pubmed:affiliation
Department of Physiology, Luzhou Medical College.
pubmed:publicationType
Journal Article, Comparative Study, English Abstract, Research Support, Non-U.S. Gov't