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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
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pubmed:dateCreated |
1996-11-25
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pubmed:abstractText |
Dominant megacolon (Dom) is one of four mutations in the mouse which can produce a phenotype similar to Hirschsprung disease in man. Here, we report that it is possible to take advantage of two microsatellite markers to genotype Dom embryos and to study enteric neuronal development in Dom embryos using whole-mount immunohistochemistry. Dom embryos present a variable defect in the ileo-caecal region, as do embryos of other murine models of Hirschsprung disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jan
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|
pubmed:issn |
0959-4965
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
7
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
489-92
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8730812-Animals,
pubmed-meshheading:8730812-Cell Movement,
pubmed-meshheading:8730812-DNA,
pubmed-meshheading:8730812-Digestive System,
pubmed-meshheading:8730812-Disease Models, Animal,
pubmed-meshheading:8730812-Female,
pubmed-meshheading:8730812-Genes, Dominant,
pubmed-meshheading:8730812-Genotype,
pubmed-meshheading:8730812-Hirschsprung Disease,
pubmed-meshheading:8730812-Immunohistochemistry,
pubmed-meshheading:8730812-Male,
pubmed-meshheading:8730812-Megacolon,
pubmed-meshheading:8730812-Mice,
pubmed-meshheading:8730812-Mice, Inbred Strains,
pubmed-meshheading:8730812-Microsatellite Repeats,
pubmed-meshheading:8730812-Neurons,
pubmed-meshheading:8730812-Phenotype,
pubmed-meshheading:8730812-Polymerase Chain Reaction,
pubmed-meshheading:8730812-Pregnancy
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pubmed:year |
1996
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|
pubmed:articleTitle |
Neuronal defects in genotyped dominant megacolon (Dom) mouse embryos, a model for Hirschsprung disease.
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pubmed:affiliation |
INSERM U91, Hôpital Henri Mondor, Créteil, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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