Linked Life Data

8730022

Source:http://linkedlifedata.com/resource/pubmed/id/8730022

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-10-22
pubmed:abstractText
Dogs are often the species of choice as an experimental model for the study of pulmonary responses to long-term exposure to air pollutants in chambers simulating environmental or occupational exposure in man. Their lungs bear a reasonable resemblance to human lungs, they are large enough to allow serial measurements of pulmonary responses, and they live long enough to ensure that findings are not confounded by aging. Several long-term canine exposure studies with ambient air pollutants have been performed since 1957: seven studies with gaseous and particulate sulphur (IV); three studies with nitrogen oxides; three studies with ozone; two studies with acidic particles; three studies with mixtures of sulphurous pollutants that might have resembled the 1952 London smog; and one study in which raw and ultra violet (UV)-irradiated motor vehicle exhaust and sulphurous pollutants were used. The findings support the hypothesis that long-term exposure to air pollutants at ambient levels might cause bronchitic lesions (sulphur oxide), emphysematous lesions (nitrogen dioxide) or fibrotic lesions (ozone). None of the studies showed an indication of synergistic effects. To improve our understanding of pulmonary responses initiated by the inhalation of pollutants over long periods of time, new concepts are needed. Investigators should consider studies with canine models of cardiopulmonary diseases, the application of novel immunological and molecular biology techniques, the phenomena of tolerance and adaptation to inhaled air pollution, and exposure atmospheres with increasing complexity, including fine and ultrafine particles.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0903-1936
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
571-84
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Long-term canine exposure studies with ambient air pollutants.
pubmed:affiliation
GSF-Forschungszentrum für Umwelt, Institute for Inhalation Biology, Oberschleissheim, Germany.
pubmed:publicationType
Journal Article, Review