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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1996-10-10
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pubmed:abstractText |
Mitochondrial DNA (mtDNA) gene defects may play a role in the development of non-insulin dependent diabetes mellitus (NIDDM). In order to search for potentially diabetogenic mtDNA defects we have applied the technique of single stranded conformational polymorphism (SSCP) analysis to 124 patients with a history of NIDDM and 40 non-diabetic controls. No new heteroplasmic mutations were detected. However, a variety of homoplasmic variants were found in patients with NIDDM; some of these merit further investigation.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-2593
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
253-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8728705-Base Sequence,
pubmed-meshheading:8728705-DNA, Mitochondrial,
pubmed-meshheading:8728705-Diabetes Mellitus, Type 2,
pubmed-meshheading:8728705-Humans,
pubmed-meshheading:8728705-Mitochondria,
pubmed-meshheading:8728705-Molecular Sequence Data,
pubmed-meshheading:8728705-Point Mutation,
pubmed-meshheading:8728705-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:8728705-RNA,
pubmed-meshheading:8728705-RNA, Transfer,
pubmed-meshheading:8728705-Reference Values,
pubmed-meshheading:8728705-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:8728705-Sequence Deletion
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pubmed:year |
1996
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pubmed:articleTitle |
Molecular scanning of candidate mitochondrial tRNA genes in type 2 (non-insulin dependent) diabetes mellitus.
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pubmed:affiliation |
Department of Medicine, University Hospital of Wales, Heath Park, Cardiff, UK.
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pubmed:publicationType |
Journal Article
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