Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1996-11-25
|
| pubmed:abstractText |
The activities of hepatic fatty acid oxidation enzymes in rats fed perilla oil rich in alpha-linolenic acid (alpha-18:3) were compared with those fed saturated fats or safflower oil (the mixture of safflower oil and olive oil, 94:8, w/w) containing the same amount of polyunsaturated fatty acids with perilla oil exclusively as linoleic acid (18:2). When the rats were fed the diets containing 15% coconut, safflower, and perilla oils for 1 week, the rate of mitochondrial and peroxisomal oxidation of palmitoyl-CoA (16:0-CoA) in the liver homogenates was the highest in rats fed perilla oil. Among the rats fed the diets containing 15% palm, safflower, and perilla oils for 2 weeks, the rates of mitochondrial and peroxisomal oxidations of 16:0-, 18:2-, and alpha-18:3-CoAs were the highest in rats fed perilla oil, and the rate of oxidation of alpha-18:3-CoA by both pathways was higher than those of other acyl-CoAs in all groups. Dietary perilla oil relative to palm and safflower oils significantly increased the activities of carnitine palmitoyltransferase, acyl-CoA dehydrogenase, acyl-CoA oxidase, and 2,4-dienoyl-CoA reductase. The substrate specificity of carnitine palmitoyltransferase appeared to be responsible for differential rates of the mitochondrial oxidation of acyl-CoAs. The substrate specificity of acyl-CoA oxidase did not account for the preferential peroxisomal oxidation of alpha-18:3 relative to 18:2. The preferential mitochondrial and peroxisomal beta-oxidation of alpha-18:3-CoA relative to 16:0- and 18:2-CoAs was also confirmed in rats fed laboratory chow irrespective of the substrate/albumin ratios in the assay mixture. It was suggested that both substrate specificities and alterations in the activities of the enzymes in beta-oxidation pathway play a significant role in the regulation of the serum lipid concentrations in rats fed a diet rich in alpha-18:3.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acyl-CoA Dehydrogenases,
http://linkedlifedata.com/resource/pubmed/chemical/Acyl-CoA Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Carnitine O-Palmitoyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats, Unsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Oils,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Albumin,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Linolenic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/perilla seed oil
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0022-2275
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
37
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
448-63
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8728310-Acyl-CoA Dehydrogenases,
pubmed-meshheading:8728310-Acyl-CoA Oxidase,
pubmed-meshheading:8728310-Animals,
pubmed-meshheading:8728310-Carnitine O-Palmitoyltransferase,
pubmed-meshheading:8728310-Dietary Fats, Unsaturated,
pubmed-meshheading:8728310-Fatty Acids,
pubmed-meshheading:8728310-Lipid Metabolism,
pubmed-meshheading:8728310-Lipids,
pubmed-meshheading:8728310-Liver,
pubmed-meshheading:8728310-Male,
pubmed-meshheading:8728310-Microbodies,
pubmed-meshheading:8728310-Mitochondria, Liver,
pubmed-meshheading:8728310-Oxidation-Reduction,
pubmed-meshheading:8728310-Oxidoreductases,
pubmed-meshheading:8728310-Plant Oils,
pubmed-meshheading:8728310-Rats,
pubmed-meshheading:8728310-Rats, Sprague-Dawley,
pubmed-meshheading:8728310-Serum Albumin,
pubmed-meshheading:8728310-Substrate Specificity,
pubmed-meshheading:8728310-Triglycerides,
pubmed-meshheading:8728310-alpha-Linolenic Acid
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Stimulation of the activities of hepatic fatty acid oxidation enzymes by dietary fat rich in alpha-linolenic acid in rats.
|
| pubmed:affiliation |
Laboratory of Nutrition Biochemistry, Ministry of Agriculture, Forestry, and Fisheries, Tsukuba Science City, Japan.
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| pubmed:publicationType |
Journal Article
|