rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
1997-1-21
|
pubmed:abstractText |
Two antigenic T-cell epitopes of HBsAg, designated HBs 16-31 and HBs 81-99, were identified using synthetic peptides and HBsAg-specific T-cell lines. HBs 16-31 was recognized by five HBsAg-specific T-cell lines from vaccinees with both high and low antibody titers, whereas HBs 81-99 was recognized by two T-cell lines derived from vaccinees with high antibody titers. The antibody titer against HBsAg was correlated significantly with the proliferation of vaccinee's PBLs in response to HBs 81-99 (r = 0.47) but not to HBs 16-31, suggesting that HBs 81-99 plays a critical role in anti-HBs antibody production in humans vaccinated with HBsAg.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0198-8859
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
46
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
93-9
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8727207-Amino Acid Sequence,
pubmed-meshheading:8727207-Epitope Mapping,
pubmed-meshheading:8727207-Epitopes,
pubmed-meshheading:8727207-HLA Antigens,
pubmed-meshheading:8727207-Hepatitis B Antibodies,
pubmed-meshheading:8727207-Hepatitis B Surface Antigens,
pubmed-meshheading:8727207-Hepatitis B Vaccines,
pubmed-meshheading:8727207-Humans,
pubmed-meshheading:8727207-Lymphocyte Cooperation,
pubmed-meshheading:8727207-Molecular Sequence Data,
pubmed-meshheading:8727207-Peptides,
pubmed-meshheading:8727207-T-Lymphocytes
|
pubmed:year |
1996
|
pubmed:articleTitle |
Identification of an epitope for T-cells correlated with antibody response to hepatitis B surface antigen in vaccinated humans.
|
pubmed:affiliation |
Department of Genetics, Medical Institute of Bioregulation, Fukuoka, Japan.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|