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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1996-11-6
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pubmed:abstractText |
The best means for optimal delivery of drugs into lungs of infants with bronchopulmonary dysplasia (BPD) is uncertain. We aimed to measure radio-aerosol deposition of salbutamol by jet nebulizer and metered dose inhalers (MDI) in ventilated and non-ventilated BPD infants. In a randomized, crossover sequence, salbutamol lung deposition was measured using an MDI (2 puffs or 200 micrograms) or sidestream jet nebulizer (5 minutes of nebulization with 100 micrograms/kg) in 10 ventilated (mean birthweight, 1,101 g) and 13 non-ventilated (mean birthweight, 1,093 g) prematurely born infants. Non-ventilated infants inhaled aerosol through a face mask, connected to a nebulizer or an MDI and spacer (Aerochamber). Ventilated infants received aerosol from an MDI + MV15 Aerochamber or a nebulizer inserted in the ventilator circuit. Lung deposition by both methods was low: mean (SEM) from the MDI was 0.67 (0.17)% of the actuated dose, and from the nebulizer it was 1.74 (0.21)% and 0.28 (0.04)% of the nebulized and initial reservoir doses, respectively. Corresponding figures for the ventilated infants were 0.98 (0.19)% from the MDI and 0.95 (0.23)% and 0.22 (0.08)% from the nebulizer. In both groups, and for both methods of delivery, there was marked inter-subject variability in lung deposition and a tendency for the aerosol to be distributed to the central lung regions.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
8755-6863
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
301-9
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pubmed:dateRevised |
2006-3-28
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pubmed:meshHeading |
pubmed-meshheading:8726155-Aerosols,
pubmed-meshheading:8726155-Albuterol,
pubmed-meshheading:8726155-Bronchopulmonary Dysplasia,
pubmed-meshheading:8726155-Cross-Over Studies,
pubmed-meshheading:8726155-Dose-Response Relationship, Drug,
pubmed-meshheading:8726155-Drug Administration Schedule,
pubmed-meshheading:8726155-Female,
pubmed-meshheading:8726155-Humans,
pubmed-meshheading:8726155-Infant,
pubmed-meshheading:8726155-Infant, Newborn,
pubmed-meshheading:8726155-Lung,
pubmed-meshheading:8726155-Male,
pubmed-meshheading:8726155-Nebulizers and Vaporizers,
pubmed-meshheading:8726155-Oxygen Inhalation Therapy
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pubmed:year |
1996
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pubmed:articleTitle |
Efficiency of aerosol medication delivery from a metered dose inhaler versus jet nebulizer in infants with bronchopulmonary dysplasia.
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pubmed:affiliation |
Department of Pediatrics, McMaster University Medical Centre, Hamilton, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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