| pubmed-article:8725401 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8725401 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:8725401 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:8725401 | lifeskim:mentions | umls-concept:C0013203 | lld:lifeskim |
| pubmed-article:8725401 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:8725401 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:8725401 | pubmed:dateCreated | 1996-9-23 | lld:pubmed |
| pubmed-article:8725401 | pubmed:abstractText | Antiviral therapy for AIDS has focused on the discovery and design of inhibitors for two main enzyme targets of the human immunodeficiency virus type 1 (HIV)--reverse transcriptase (RT) and protease (PR). Despite several classes of promising new anti-HIV agents, the clinical emergence of drug-resistant variants of HIV has severely limited the long-term effectiveness of these drugs. Genetic analysis of resistant virus has identified a number of critical mutations in the RT and PR genes. Structural analysis of inhibitor-enzyme complexes and mutational modeling studies are leading to a better understanding of how these drug-resistance mutations exert their effects at a structural level. These insights have implications of the design of new drugs and therapeutic strategies to combat drug resistance to AIDS. | lld:pubmed |
| pubmed-article:8725401 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8725401 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8725401 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8725401 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8725401 | pubmed:issn | 0362-1642 | lld:pubmed |
| pubmed-article:8725401 | pubmed:author | pubmed-author:EricksonJ WJW | lld:pubmed |
| pubmed-article:8725401 | pubmed:author | pubmed-author:BALZFF | lld:pubmed |
| pubmed-article:8725401 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8725401 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:8725401 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8725401 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8725401 | pubmed:pagination | 545-71 | lld:pubmed |
| pubmed-article:8725401 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:8725401 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8725401 | pubmed:articleTitle | Structural mechanisms of HIV drug resistance. | lld:pubmed |
| pubmed-article:8725401 | pubmed:affiliation | Structural Biochemistry Program, Frederick Biomedical Supercomputing Center, SAIC-Frederick, NCI-Frederick Cancer Research and Development Center, Maryland 21702, USA. | lld:pubmed |
| pubmed-article:8725401 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8725401 | pubmed:publicationType | Review | lld:pubmed |
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