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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1996-9-23
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pubmed:abstractText |
Antiviral therapy for AIDS has focused on the discovery and design of inhibitors for two main enzyme targets of the human immunodeficiency virus type 1 (HIV)--reverse transcriptase (RT) and protease (PR). Despite several classes of promising new anti-HIV agents, the clinical emergence of drug-resistant variants of HIV has severely limited the long-term effectiveness of these drugs. Genetic analysis of resistant virus has identified a number of critical mutations in the RT and PR genes. Structural analysis of inhibitor-enzyme complexes and mutational modeling studies are leading to a better understanding of how these drug-resistance mutations exert their effects at a structural level. These insights have implications of the design of new drugs and therapeutic strategies to combat drug resistance to AIDS.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0362-1642
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
545-71
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8725401-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:8725401-Antiviral Agents,
pubmed-meshheading:8725401-Drug Design,
pubmed-meshheading:8725401-Drug Resistance, Microbial,
pubmed-meshheading:8725401-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:8725401-HIV Protease,
pubmed-meshheading:8725401-HIV Protease Inhibitors,
pubmed-meshheading:8725401-HIV Reverse Transcriptase,
pubmed-meshheading:8725401-HIV-1,
pubmed-meshheading:8725401-Humans,
pubmed-meshheading:8725401-Mutation,
pubmed-meshheading:8725401-RNA-Directed DNA Polymerase,
pubmed-meshheading:8725401-Reverse Transcriptase Inhibitors,
pubmed-meshheading:8725401-Structure-Activity Relationship
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pubmed:year |
1996
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pubmed:articleTitle |
Structural mechanisms of HIV drug resistance.
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pubmed:affiliation |
Structural Biochemistry Program, Frederick Biomedical Supercomputing Center, SAIC-Frederick, NCI-Frederick Cancer Research and Development Center, Maryland 21702, USA.
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pubmed:publicationType |
Journal Article,
Review
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