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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1996-10-25
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pubmed:databankReference |
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pubmed:abstractText |
We investigated the molecular mechanism of 50 penicillin-resistant Streptococcus pneumoniae strains (penicillin: MIC, > or = 0.125 microgram/ml) having neither class A nor class B mutations in the penicillin-binding protein 2B gene (pbp2b). An analysis of the nucleotide sequences of the pbp2b genes from seven strains revealed an unique direct repeat of 9 nucleotides (TGGTATACT) between active-site serine (residue 385) and Ser-X-Asn (residues 442 to 444) motifs. The same insertion was detected in 13 strains.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8723477-1617076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8723477-1629327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8723477-2120542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8723477-2654541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8723477-2668874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8723477-2798106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8723477-2813426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8723477-3405266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8723477-3848294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8723477-7729674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8723477-7785985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8723477-8412708
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aminoacyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Transposable Elements,
http://linkedlifedata.com/resource/pubmed/chemical/Hexosyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Muramoylpentapeptide...,
http://linkedlifedata.com/resource/pubmed/chemical/Penicillin-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptidyl Transferases,
http://linkedlifedata.com/resource/pubmed/chemical/penicillin-binding protein 2b...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1257-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8723477-Amino Acid Sequence,
pubmed-meshheading:8723477-Aminoacyltransferases,
pubmed-meshheading:8723477-Bacterial Proteins,
pubmed-meshheading:8723477-Base Sequence,
pubmed-meshheading:8723477-Carrier Proteins,
pubmed-meshheading:8723477-DNA, Bacterial,
pubmed-meshheading:8723477-DNA Transposable Elements,
pubmed-meshheading:8723477-Genes, Bacterial,
pubmed-meshheading:8723477-Hexosyltransferases,
pubmed-meshheading:8723477-Molecular Sequence Data,
pubmed-meshheading:8723477-Muramoylpentapeptide Carboxypeptidase,
pubmed-meshheading:8723477-Mutation,
pubmed-meshheading:8723477-Nucleic Acid Hybridization,
pubmed-meshheading:8723477-Penicillin Resistance,
pubmed-meshheading:8723477-Penicillin-Binding Proteins,
pubmed-meshheading:8723477-Peptidyl Transferases,
pubmed-meshheading:8723477-Streptococcus pneumoniae
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pubmed:year |
1996
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pubmed:articleTitle |
Directly repeated insertion of 9-nucleotide sequence detected in penicillin-binding protein 2B gene of penicillin-resistant Streptococcus pneumoniae.
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pubmed:affiliation |
Institute for Biotechnology Research, Wakunaga Pharmaceutical Co., Ltd., Hiroshima, Japan.
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pubmed:publicationType |
Journal Article
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