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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1996-9-26
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pubmed:abstractText |
The chromatin structure of the mouse peripherin gene domain was analyzed in peripherin-positive and -negative cell lines. At least nine DNase I hypersensitive sites (HSS) are present within the 20-kb peripherin domain in the mouse neuroblastoma cell lines which express peripherin. Three of them are situated in intron I and intron III, the others being distributed within the 5' flanking region up to -5.5 kb. The presence of these sites was also investigated in the peripherin chromatin domain of peripherin-negative cell lines. Two other types of HSS distribution were observed along the peripherin gene according to the category of cell considered: constantly peripherin-negative cells, or negative cells arising from transiently peripherin-expressing precursors. From comparison of HSS patterns in these cell lines with those of neuroblastoma cells, it can be predicted that HSS located in the region -1500/+800 bp participate in cell-specific expression of the mouse peripherin gene.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chromatin,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyribonuclease I,
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intermediate Filament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/peripherin
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0360-4012
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
115-23
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8723219-3T3 Cells,
pubmed-meshheading:8723219-Animals,
pubmed-meshheading:8723219-Cell Line,
pubmed-meshheading:8723219-Chromatin,
pubmed-meshheading:8723219-DNA,
pubmed-meshheading:8723219-DNA, Neoplasm,
pubmed-meshheading:8723219-Deoxyribonuclease I,
pubmed-meshheading:8723219-Eye Proteins,
pubmed-meshheading:8723219-Insulinoma,
pubmed-meshheading:8723219-Intermediate Filament Proteins,
pubmed-meshheading:8723219-Introns,
pubmed-meshheading:8723219-Melanoma, Experimental,
pubmed-meshheading:8723219-Membrane Glycoproteins,
pubmed-meshheading:8723219-Mice,
pubmed-meshheading:8723219-Nerve Tissue Proteins,
pubmed-meshheading:8723219-Neuroblastoma,
pubmed-meshheading:8723219-Neuropeptides,
pubmed-meshheading:8723219-Pancreatic Neoplasms,
pubmed-meshheading:8723219-Pituitary Neoplasms,
pubmed-meshheading:8723219-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:8723219-Schwann Cells,
pubmed-meshheading:8723219-Tumor Cells, Cultured
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pubmed:year |
1996
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pubmed:articleTitle |
Three different states of the chromatin structure of the mouse peripherin gene.
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pubmed:affiliation |
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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