Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-9-20
pubmed:abstractText
Fasting plasma cholesterol, triglycerides, high-density lipoprotein (HDL) and apoprotein (apo) B were elevated in 214 nondiabetic renal transplant recipients when compared to a reference group. Apo (a) was slightly but not significantly lower in transplant recipients (median 118 mg/dl, range 16-1680 vs 130 mg/dl, 10-1176) and this difference could be predicted from Lp (a) isoform analysis. Cholesterol, triglyceride, apo B and apo (a) concentrations correlated negatively with creatinine clearance but none of these parameters showed a significant association with proteinuria. Patients treated with steroids had higher plasma HDL concentrations than those receiving cyclosporin monotherapy (P < 0.01). The use of diuretics was associated with raised triglycerides (P < 0.001) and cholesterol (P < 0.01) and with reduced HDL (P < 0.01) whilst patients receiving beta-blockers had significantly higher triglycerides (P < 0.01) and lower HDL levels (P < 0.02). In multiple regression analysis, age (P < 0.01), creatinine clearance (P < 0.05) and diuretic therapy (P < 0.005) were independent risk factors for increased cholesterol whilst apo (a) levels correlated negatively with creatinine clearance (P < 0.005). These results suggest that impaired renal function, steroids and non-immunosuppressive drugs contribute to lipid abnormalites in renal transplant recipients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein A-I, http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins B, http://linkedlifedata.com/resource/pubmed/chemical/Apoprotein(a), http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, http://linkedlifedata.com/resource/pubmed/chemical/Creatinine, http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine, http://linkedlifedata.com/resource/pubmed/chemical/Diuretics, http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents, http://linkedlifedata.com/resource/pubmed/chemical/Lipoprotein(a), http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, HDL, http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL, http://linkedlifedata.com/resource/pubmed/chemical/Prednisolone, http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
pubmed:status
MEDLINE
pubmed:issn
0934-0874
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
221-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8723190-Adrenergic beta-Antagonists, pubmed-meshheading:8723190-Adult, pubmed-meshheading:8723190-Apolipoprotein A-I, pubmed-meshheading:8723190-Apolipoproteins, pubmed-meshheading:8723190-Apolipoproteins B, pubmed-meshheading:8723190-Apoprotein(a), pubmed-meshheading:8723190-Cholesterol, pubmed-meshheading:8723190-Creatinine, pubmed-meshheading:8723190-Cyclosporine, pubmed-meshheading:8723190-Diuretics, pubmed-meshheading:8723190-Female, pubmed-meshheading:8723190-Humans, pubmed-meshheading:8723190-Hyperlipidemias, pubmed-meshheading:8723190-Immunosuppressive Agents, pubmed-meshheading:8723190-Kidney Transplantation, pubmed-meshheading:8723190-Lipoprotein(a), pubmed-meshheading:8723190-Lipoproteins, pubmed-meshheading:8723190-Lipoproteins, HDL, pubmed-meshheading:8723190-Lipoproteins, LDL, pubmed-meshheading:8723190-Male, pubmed-meshheading:8723190-Phenotype, pubmed-meshheading:8723190-Prednisolone, pubmed-meshheading:8723190-Regression Analysis, pubmed-meshheading:8723190-Risk Factors, pubmed-meshheading:8723190-Triglycerides
pubmed:year
1996
pubmed:articleTitle
Factors influencing plasma lipid profiles including lipoprotein (a) concentrations in renal transplant recipients.
pubmed:affiliation
Renal Transplant Unit, Cardiff Royal Infirmary, Wales, UK.
pubmed:publicationType
Journal Article