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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1996-10-24
|
| pubmed:abstractText |
A previous analysis found a relatively high rate of alcoholism in a cohort of bipolar I subjects, and a trend for increased rates of alcoholism in relatives of subjects with both bipolar I disorder and alcoholism, compared to relatives of subjects with bipolar I disorder and no alcoholism. The sample of subjects with bipolar I disorder has been enlarged through continued follow-up, permitting new analyses to address the association and heritability of bipolar I disorder with alcoholism. Probands with bipolar I disorder were followed for 10 years as part of the NIMH Collaborative Depression Study. The rate of alcoholism in relatives of probands with both bipolar I disorder and alcoholism was compared to the rate of alcoholism in relatives of probands with bipolar disorder and no alcoholism. The prevalence of alcoholism in relatives of subjects with bipolar I disorder was compared to the rate of alcoholism in relatives of control subjects. Relatives of probands with bipolar I disorder showed a higher rate of alcoholism than relatives of controls. Relatives of probands with bipolar I disorder and alcoholism showed a higher rate of alcoholism than relatives of probands with bipolar I disorder without alcoholism. These data suggest that familial alcoholism may contribute to a vulnerability to bipolar I disorder, and that there is a shared heritability for the two disorders.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0148-7299
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
9
|
| pubmed:volume |
67
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
197-201
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8723047-Adult,
pubmed-meshheading:8723047-Age of Onset,
pubmed-meshheading:8723047-Alcoholism,
pubmed-meshheading:8723047-Bipolar Disorder,
pubmed-meshheading:8723047-Female,
pubmed-meshheading:8723047-Follow-Up Studies,
pubmed-meshheading:8723047-Humans,
pubmed-meshheading:8723047-Longitudinal Studies,
pubmed-meshheading:8723047-Male,
pubmed-meshheading:8723047-Retrospective Studies
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Familial alcoholism in manic-depressive (bipolar) disease.
|
| pubmed:affiliation |
National Institute of Mental Health Collaborative Program on the Psychobiology of Depression, Clinical Studies, Washington, DC, USA.
|
| pubmed:publicationType |
Journal Article
|