Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1996-9-23
|
| pubmed:abstractText |
Oxidation of low-density lipoprotein (LDL) is considered to be the initial step in the atherosclerotic process. Autoantibodies to oxidized LDL (ox-LDL) have been detected in human serum. We used an enzyme-linked immunosorbent assay technique to measure autoantibody titers in 63 normal subjects and patients with coronary artery disease. Thirty-five patients underwent coronary angiography for suspected coronary artery disease. Patients were divided into the following categories: group 1, 20 healthy young volunteers; group 2, 8 patients age-matched to the catheterization patients; group 3, 10 patients with normal coronary angiograms; and group 4, 25 patients with angiographic coronary artery disease. Autoantibody titers to ox-LDL were group 1, 0.142 +/- 0.023; group 2, 0.197 +/- 0.039; group 3, 0.183 +/- 0.038; and group 4, 0.340 +/- 0.026. There was no statistical difference among groups 1, 2, and 3, but the difference between these groups and group 4 was highly significant (p < 0.05). This study demonstrates that (1) autoantibodies to ox-LDL can be detected in normal subjects and in patients with abnormal coronary angiograms and (2) significantly higher titers of autoantibodies to ox-LDL were seen in patients with angiographic evidence of coronary artery disease.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0002-8703
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
131
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
663-7
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8721636-Adult,
pubmed-meshheading:8721636-Autoantibodies,
pubmed-meshheading:8721636-Coronary Angiography,
pubmed-meshheading:8721636-Coronary Artery Disease,
pubmed-meshheading:8721636-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:8721636-Female,
pubmed-meshheading:8721636-Humans,
pubmed-meshheading:8721636-Lipid Peroxidation,
pubmed-meshheading:8721636-Lipids,
pubmed-meshheading:8721636-Lipoproteins, LDL,
pubmed-meshheading:8721636-Male,
pubmed-meshheading:8721636-Middle Aged
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Autoantibody titers to oxidized low-density lipoprotein in patients with coronary atherosclerosis.
|
| pubmed:affiliation |
Department of Internal Medicine, Georgetown University Medical Center, Washington, D.C. 20007, USA.
|
| pubmed:publicationType |
Journal Article
|