Linked Life Data

8719618

Source:http://linkedlifedata.com/resource/pubmed/id/8719618

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1997-3-6
pubmed:abstractText
InsP3-gated channels present in isolated rat olfactory cilia membranes were studied by recording current fluctuations in cilia membranes fused onto phospholipid bilayers formed at the tip of a patch pipette. We found that InsP3 (1.25 to 30 microM) induced current fluctuations in 18 of 157 otherwise silent bilayers. The ion channels opened by InsP3 could be classified into two groups that differed in terms of conductance and kinetics. One channel, which had a conductance of 37 pS, displayed two current levels, and the larger single channel currents were associated with longer open dwell times. The other channel displayed a larger conductance (103-184 pS). Both types of channels displayed reversal potentials near zero millivolts, consistent with nonspecific cation channels. These experiments suggest that mammalian olfactory neurons possess two types of ciliary InsP3-gated channels.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
12
pubmed:volume
703
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
79-85
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
InsP3-gated ion channels in rat olfactory cilia membrane.
pubmed:affiliation
Department of Physiology, Kyushu Dental College, Kitakyushu, Japan.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.