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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6 Pt 1
|
| pubmed:dateCreated |
1996-9-27
|
| pubmed:abstractText |
Currently the sole method available for diagnosis of heart allograft rejection is endomyocardial biopsy. Although this procedure offers important criteria for treatment, it cannot always discriminate between mild episodes of rejection which might be self-limiting and forms which may progress. In an effort to monitor rejection, we have implemented a cellular monitoring strategy aimed at identifying episodes of rejection in biopsy specimens which may evolve into higher grades of rejection. The lymphocyte growth assay is based on the capacity of interleukin-2 receptor-positive T cells to expand in the presence of interleukin-2 and antigen provided by the biopsy fragment. In this study we investigated whether a positive lymphocyte growth assay correlated with and was predictive of subsequent histologic allograft rejection and the development of anti-human leukocyte antigen antibodies.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1053-2498
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1156-61
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8719463-Adult,
pubmed-meshheading:8719463-Aged,
pubmed-meshheading:8719463-Biopsy,
pubmed-meshheading:8719463-Endocardium,
pubmed-meshheading:8719463-Female,
pubmed-meshheading:8719463-Graft Rejection,
pubmed-meshheading:8719463-Heart Transplantation,
pubmed-meshheading:8719463-Humans,
pubmed-meshheading:8719463-Immunosuppressive Agents,
pubmed-meshheading:8719463-Interleukin-2,
pubmed-meshheading:8719463-Lymphocyte Activation,
pubmed-meshheading:8719463-Male,
pubmed-meshheading:8719463-Middle Aged,
pubmed-meshheading:8719463-Monitoring, Immunologic,
pubmed-meshheading:8719463-Myocardium,
pubmed-meshheading:8719463-Predictive Value of Tests,
pubmed-meshheading:8719463-T-Lymphocytes,
pubmed-meshheading:8719463-Transplantation, Homologous
|
| pubmed:articleTitle |
Additive value of immunologic monitoring to histologic grading of heart allograft biopsy specimens: implications for therapy.
|
| pubmed:affiliation |
College of Physicians and Surgeons of Columbia University, Department of Pathology, New York, New York 10032, USA.
|
| pubmed:publicationType |
Journal Article
|