Linked Life Data

8714764

Source:http://linkedlifedata.com/resource/pubmed/id/8714764

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-10-2
pubmed:abstractText
Responses of isolated skin melanophores of Rana tigerina and Bufo melanostictus to cholinergic drugs were studied using the Mean Melanophore Size Index assay to explore the nature and role of cellular receptors in melanophore regulation activity. Acetylcholine (Ach) in a concentration of 10(-7) to 6.4 x 10(-6) g/ml caused dispersion of the skin melanophores of R. tigerina and B. melanostictus. These effects were blocked by both atropine and hyoscine in a concentration of 8 x 10(-6) g/ml each. Eserine augmented the melanophore dispersal effects of Ach. This potentiation of the dispersal effect of Ach by eserine was also antagonised by hyoscine. Carbachol another specific cholinergic agonist significantly caused dispersion of the melanophores of both the amphibian species. The effects were also blocked by atropine and hyoscine. These data indicate that cholinergic receptors of muscarinic type are present on the melanophores of R. tigerina and B. melanostictus which mediate dispersion of integumental melanophores leading to darkening of the skin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0236-5383
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
61-73
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Role of cholinergic receptors in melanophore responses of amphibians.
pubmed:affiliation
PG Zoology Department, Saifia Postgraduate College of Science and Education, Bhopal, India.
pubmed:publicationType
Journal Article, In Vitro