Linked Life Data

8713739

Source:http://linkedlifedata.com/resource/pubmed/id/8713739

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-11-14
pubmed:abstractText
Pregnancy is characterized by increases in both blood and interstitial volumes, but the mechanisms are unknown. To test the hypotheses that blood volume (BV) recovery after haemorrhage in pregnant (P) is faster than in nonpregnant (NP) rabbits, and that this can be explained by a higher capillary filtration, a 20% BV haemorrhage was produced in a group of 7 P and 7 NP rabbits. We determined the BV recovery (measured by 99Tc), the total plasma protein mass and the haematocrit at 10, 20, 30, 60 and 1440 min after haemorrhage. Arterial and venous pressures and heart rate were measured during a 30-min control period, during the 10 min of haemorrhage, and for the following 70 min. In a separate group of P and NP rabbits, 125I-labelled albumin was infused and blood samples were obtained at 10, 20, and 30 min. Capillary filtration was expressed as the percentage of radioactive albumin that left the intravascular space after 30 min. No differences were found in the rate of BV recovery, arterial and venous pressures, or heart rate response between P and NP animals (P > 0.1). By 24 h total plasma protein mass (TPPM) was significantly increased above baseline in the P rabbits by an average+SEM of 13 + 3.7%, but not in NP rabbits (5 + 4.5%). At 30 min, the amount of labelled albumin in the intravascular space decreased by 15.4 + 3.4% for Pv. 8.2 + 1.2% for NP rabbits (P < 0.05). There was a high correlation between TPPM recovery and BV recovery in the P (r = 0.96) and NP rabbits (r = 0.95). In conclusion, we did not find differences in the rate at which the BV recovered during pregnancy, despite the increased capillary permeability. During pregnancy, the combination of the latter with an increase in the TPPM elevation above pre-haemorrhage levels suggests a faster rate of protein mobilization.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1031-3613
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
183-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Transvascular albumin transport and protein replenishment after haemorrhage in the chronically catheterized pregnant rabbit.
pubmed:affiliation
Division of Perinatal Biology, Loma Linda University, San Bernardino County Medical Center, CA 92415-0935, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't