|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4A
|
|
pubmed:dateCreated |
1996-9-10
|
|
pubmed:abstractText |
To gain insights into the involvement of kinases in the growth control of prostate carcinoma cells by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), immunoblot analysis and in vitro phosphorylation assays were performed using kinase discriminating effectors and extracts prepared from the androgen-dependent LNCaP and the androgen-independent JCA-1 human prostate cells. The down-regulation of PKC-alpha and -beta in JCA-1 cells was correlated with the effects of TPA. In LNCaP cells, proliferation may involve DNA-PK, proposed to act possibly via phosphorylation of the androgen receptor.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Activated Protein Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dihydrotestosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PRKCA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PRKDC protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Poly dA-dT,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Androgen,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/protein kinase C beta
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0250-7005
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
16
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1843-9
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:8712711-Cell Cycle,
pubmed-meshheading:8712711-Cell Division,
pubmed-meshheading:8712711-Cell Line,
pubmed-meshheading:8712711-DNA-Activated Protein Kinase,
pubmed-meshheading:8712711-DNA-Binding Proteins,
pubmed-meshheading:8712711-Dihydrotestosterone,
pubmed-meshheading:8712711-Humans,
pubmed-meshheading:8712711-Isoenzymes,
pubmed-meshheading:8712711-Kinetics,
pubmed-meshheading:8712711-Male,
pubmed-meshheading:8712711-Nuclear Proteins,
pubmed-meshheading:8712711-Phosphoproteins,
pubmed-meshheading:8712711-Phosphorylation,
pubmed-meshheading:8712711-Poly dA-dT,
pubmed-meshheading:8712711-Prostatic Neoplasms,
pubmed-meshheading:8712711-Protein Kinase C,
pubmed-meshheading:8712711-Protein Kinase C-alpha,
pubmed-meshheading:8712711-Protein Kinases,
pubmed-meshheading:8712711-Protein-Serine-Threonine Kinases,
pubmed-meshheading:8712711-Receptors, Androgen,
pubmed-meshheading:8712711-Tetradecanoylphorbol Acetate,
pubmed-meshheading:8712711-Tumor Cells, Cultured
|
|
pubmed:articleTitle |
Growth control of human prostatic cancer cells by the phorbol ester TPA: possible involvement of protein kinases.
|
|
pubmed:affiliation |
Department of Urology, New York Medical College, Valhalla 10595, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
