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pubmed-article:8712700pubmed:abstractTextPeripheral blood cells of cancer patients with advanced renal carcinoma and treated with interleukin-2 by intravenous application were studied by electron microscopy at different intervals from the beginning of rIL-2 administration. Morphofunctional modifications of lymphocytes, circulating hystiocytes containing phagocitated bodies and polimorphonucleated cells undergoing phagocytosis were observed with a time dependent increase of altered cells. The analysis of blood cells cultured in the presence of recombinant IL-2 confirmed the in vivo results. Our data suggest that IL-2 induces apoptotic phenomena in the peripheral blood cells of treated patients.lld:pubmed
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pubmed-article:8712700pubmed:articleTitleCell activation and death (apoptosis) induced by IL-2: ultrastructural evidence.lld:pubmed
pubmed-article:8712700pubmed:affiliationDipartimento di Genetica e Microbiologia, Università di Pavia, Italy.lld:pubmed
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