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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4A
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pubmed:dateCreated |
1996-9-10
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pubmed:abstractText |
Peripheral blood cells of cancer patients with advanced renal carcinoma and treated with interleukin-2 by intravenous application were studied by electron microscopy at different intervals from the beginning of rIL-2 administration. Morphofunctional modifications of lymphocytes, circulating hystiocytes containing phagocitated bodies and polimorphonucleated cells undergoing phagocytosis were observed with a time dependent increase of altered cells. The analysis of blood cells cultured in the presence of recombinant IL-2 confirmed the in vivo results. Our data suggest that IL-2 induces apoptotic phenomena in the peripheral blood cells of treated patients.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1775-80
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8712700-Apoptosis,
pubmed-meshheading:8712700-Carcinoma, Renal Cell,
pubmed-meshheading:8712700-Cells, Cultured,
pubmed-meshheading:8712700-Humans,
pubmed-meshheading:8712700-Interleukin-2,
pubmed-meshheading:8712700-Kidney Neoplasms,
pubmed-meshheading:8712700-Lymphocyte Activation,
pubmed-meshheading:8712700-Lymphocytes,
pubmed-meshheading:8712700-Microscopy, Electron,
pubmed-meshheading:8712700-Recombinant Proteins,
pubmed-meshheading:8712700-Reference Values,
pubmed-meshheading:8712700-Time Factors
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pubmed:articleTitle |
Cell activation and death (apoptosis) induced by IL-2: ultrastructural evidence.
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pubmed:affiliation |
Dipartimento di Genetica e Microbiologia, Università di Pavia, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study
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