| pubmed-article:8712678 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8712678 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:8712678 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8712678 | lifeskim:mentions | umls-concept:C0677886 | lld:lifeskim |
| pubmed-article:8712678 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:8712678 | lifeskim:mentions | umls-concept:C0017066 | lld:lifeskim |
| pubmed-article:8712678 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:8712678 | lifeskim:mentions | umls-concept:C1336633 | lld:lifeskim |
| pubmed-article:8712678 | lifeskim:mentions | umls-concept:C1160185 | lld:lifeskim |
| pubmed-article:8712678 | lifeskim:mentions | umls-concept:C0332283 | lld:lifeskim |
| pubmed-article:8712678 | pubmed:issue | 4A | lld:pubmed |
| pubmed-article:8712678 | pubmed:dateCreated | 1996-9-10 | lld:pubmed |
| pubmed-article:8712678 | pubmed:abstractText | In an effort to develop gene therapy for ovarian cancer efficacy and toxicity of adenovirus-mediated transfer of the HSV-TK gene followed by administration of ganciclovir were studied in two human epithelial ovarian cancer cell lines Ov-ca-2774 and Ov-ca-1225. 100% transduction was achieved in both cell lines at MOIs of 7 and 15 as demonstrated by X-Gal staining. No toxicity of virus alone was observed at MOIs up to 30. GCV was not toxic up to 200 micrograms/ml. Cell killing efficacy was shown to be dependent on MOI as well as GCV dose. The "bystander effect" of ADV/RSV-TK was quantified by mixing experiments and found to be dependent on the proportion of ADV/RSV-TK positive cells as well as the GCV dosage. Similar results were observed in both cell lines. ADV/RSV-TK mediated gene therapy may be a promising approach in ovarian cancer. | lld:pubmed |
| pubmed-article:8712678 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8712678 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8712678 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8712678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8712678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8712678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8712678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8712678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8712678 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8712678 | pubmed:issn | 0250-7005 | lld:pubmed |
| pubmed-article:8712678 | pubmed:author | pubmed-author:WooS LSL | lld:pubmed |
| pubmed-article:8712678 | pubmed:author | pubmed-author:ChenS HSH | lld:pubmed |
| pubmed-article:8712678 | pubmed:author | pubmed-author:BlochFF | lld:pubmed |
| pubmed-article:8712678 | pubmed:author | pubmed-author:KiebackD GDG | lld:pubmed |
| pubmed-article:8712678 | pubmed:author | pubmed-author:TongX WXW | lld:pubmed |
| pubmed-article:8712678 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8712678 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:8712678 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8712678 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8712678 | pubmed:pagination | 1611-7 | lld:pubmed |
| pubmed-article:8712678 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:8712678 | pubmed:meshHeading | pubmed-meshheading:8712678-... | lld:pubmed |
| pubmed-article:8712678 | pubmed:meshHeading | pubmed-meshheading:8712678-... | lld:pubmed |
| pubmed-article:8712678 | pubmed:meshHeading | pubmed-meshheading:8712678-... | lld:pubmed |
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| pubmed-article:8712678 | pubmed:meshHeading | pubmed-meshheading:8712678-... | lld:pubmed |
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| pubmed-article:8712678 | pubmed:meshHeading | pubmed-meshheading:8712678-... | lld:pubmed |
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| pubmed-article:8712678 | pubmed:meshHeading | pubmed-meshheading:8712678-... | lld:pubmed |
| pubmed-article:8712678 | pubmed:meshHeading | pubmed-meshheading:8712678-... | lld:pubmed |
| pubmed-article:8712678 | pubmed:meshHeading | pubmed-meshheading:8712678-... | lld:pubmed |
| pubmed-article:8712678 | pubmed:meshHeading | pubmed-meshheading:8712678-... | lld:pubmed |
| pubmed-article:8712678 | pubmed:meshHeading | pubmed-meshheading:8712678-... | lld:pubmed |
| pubmed-article:8712678 | pubmed:articleTitle | Adenovirus-mediated thymidine kinase gene transduction in human epithelial ovarian cancer cell lines followed by exposure to ganciclovir. | lld:pubmed |
| pubmed-article:8712678 | pubmed:affiliation | Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA. | lld:pubmed |
| pubmed-article:8712678 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8712678 | lld:pubmed |
